1-(2,2-Dimethylvaleryl)-piperidin | 13146-38-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(2,2-Dimethylvaleryl)-piperidin
• 英文别名: 1-(2,2-dimethyl-pentanoyl)-piperidine；2,2-Dimethyl-1-piperidin-1-ylpentan-1-one
• CAS: 13146-38-8
• 化学式: C₁₂H₂₃NO
• 分子量: 197.321
• InChiKey: JHDDUGYWFYJXIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION
  申请人：Nurix Therapeutics, Inc.

  公开号：US20220387395A1

  公开（公告）日：2022-12-08

  Compounds of formulae (I) and (II), compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo.
• [EN] 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS<br/>[FR] INHIBITEURS DE PROTÉINE D'ACTIVATION DE LA 5-LIPOXYGÉNASE (FLAP)
  申请人：AMIRA PHARMACEUTICALS INC

  公开号：WO2008141011A1

  公开（公告）日：2008-11-20

  [EN] Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
  [FR] L'invention concerne des composés et des compositions pharmaceutiques contenant de tels composés, qui modulent l'activité de la protéine d'activation de la 5-lipoxygénase (FLAP). Sont également décrits ici des procédés d'utilisation de tels modulateurs de FLAP, seuls et en combinaison avec d'autres composés, pour traiter des affections ou des troubles respiratoires, cardiovasculaires et autres dépendant des leukotriènes ou véhiculés par les leukotriènes.