S-Adenosylmethionin | 79845-28-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: S-Adenosylmethionin
• 英文别名: (3S)-5'-[(3-amino-3-carboxylatopropyl)methylsulphonio]-5'-deoxyadenosine
• CAS: 79845-28-6
• 化学式: C₁₅H₂₃N₆O₅S
• 分子量: 399.451
• InChiKey: MEFKEPWMEQBLKI-XSNYTKKPSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -1.92
• 重原子数：
  27.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  182.63
• 氢给体数：
  5.0
• 氢受体数：
  10.0

文献信息

• [EN] STABLE INDOLE-3-PROPIONATE SALTS OF S-ADENOSYL-L-METHIONINE<br/>[FR] SELS D'INDOLE-3-PROPIONATE STABLES DE LA S-ADÉNOSYL-L-MÉTHIONINE
  申请人：HEBERT SAM E LLC

  公开号：WO2014113609A1

  公开（公告）日：2014-07-24

  Stable indole-3-propionic acid salts of S-adenosyl-L-methionine, or a pharmaceutically acceptable salt thereof, are disclosed, as well as pharmaceutical compositions comprising the indole-3-propionic acid salts, methods of using the indole-3-propionic acid salts and processes for making same.

  本发明公开了稳定的S-腺苷甲硫氨酸的吲哚-3-丙酸盐，或其药用可接受的盐，以及包含吲哚-3-丙酸盐的药物组合物，使用吲哚-3-丙酸盐的方法和制备方法。
• Slow-release solid oral compositions
  申请人：GNOSIS SPA

  公开号：US10702482B2

  公开（公告）日：2020-07-07

  The present invention relates to a slow-release solid oral nutraceutical and/or pharmaceutical composition comprising: a core containing a donor of methyl groups and at least one pharmaceutically acceptable excipient, and an outer coating containing shellac and/or a pharmaceutically acceptable salt thereof, magnesium stearate, and at least one pharmaceutically acceptable excipient. The coating of said solid oral composition allows the donor of methyl groups, preferably SAMe and/or a pharmaceutically acceptable salt thereof, to cross intact the gastric barrier and release the same in a continuous and complete manner along the entire digestive tract.

  本发明涉及一种缓释固体口服营养保健品和/或药物组合物，包括：含有甲基基团供体和至少一种药学上可接受的赋形剂的核心，以及含有虫胶和/或其药学上可接受的盐、硬脂酸镁和至少一种药学上可接受的赋形剂的外涂层。所述固体口服组合物的涂层可使甲基基团的供体，最好是 SAMe 和/或其药学上可接受的盐，完整地穿过胃屏障，并在整个消化道中以连续和完整的方式释放出来。
• Enantiomers of S-adenosyl-l-methionine
  申请人：——

  公开号：US20020025926A1

  公开（公告）日：2002-02-28

  Enantiomers of S-adenosyl-l-methionine, their stable salts and their uses are described. These compositions possess potent activity in treating various conditions involving hypomethylation and transulfuration reactions and are valuable for use as active constituents in pharmaceutical compositions.

  描述了 S-腺苷-l-蛋氨酸的对映体、它们的稳定盐及其用途。这些成分在治疗涉及低甲基化和转硫化反应的各种病症方面具有强效活性，可用作药物成分中的活性成分。
• Process for the preparation of pharmaceutically acceptable salts of (R,S)-S-adenosyl-L-methionine
  申请人：——

  公开号：US20020173012A1

  公开（公告）日：2002-11-21

  The present invention relates to a process for the preparation of pharmaceutically acceptable salts of (SS,RS)-S-adenosyl-L-methionine and allows to obtain the salified (RS)-(+)-S-adenosyl-L-methionine diastereoisomer in amounts lower than or equal to 3% with respect to the salified (SS)-(+)-S-adenosyl-L-methionine diastereoisomer; the salts that can be obtained by the process of the invention keep their configuration stable in time.

  本发明涉及一种制备(SS,RS)-S-腺苷-L-蛋氨酸的药学上可接受的盐的工艺，可以获得盐化的(RS)-(+)-S-腺苷-L-蛋氨酸非对映异构体，其用量低于或等于盐化的(SS)-(+)-S-腺苷-L-蛋氨酸非对映异构体的3%；通过本发明的工艺可以获得的盐在一定时间内保持其构型稳定。
• Stable compositions of S-adenosyl-l-methionine with dextran
  申请人：——

  公开号：US20030144244A1

  公开（公告）日：2003-07-31

  Stable compositions of S-adenosyl-l-methionine with dextran are described. The compositions according to the invention are stable over time and are valuable for use as active constituents in pharmaceutical and cosmeceutical preparations.

  本发明描述了 S-腺苷-l-蛋氨酸与葡聚糖的稳定组合物。本发明的组合物具有长期稳定性，可用作药物和化妆品制剂中的活性成分。