[1-(Oxetan-3-yl)piperidin-4-yl]methanamine | 1349717-14-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [1-(Oxetan-3-yl)piperidin-4-yl]methanamine
• CAS: 1349717-14-1
• 化学式: C₉H₁₈N₂O
• 分子量: 170.25
• InChiKey: GIZLTNAJGHPXLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• N-(PHENYLSULFONYL)BENZAMIDE DERIVATIVES AS BCL-2 INHIBITORS
  申请人：The Regents of The University of Michigan

  公开号：EP3494115B1

  公开（公告）日：2020-10-21
• BCL-2 INHIBITORS
  申请人：BEIGENE, LTD.

  公开号：US20220402915A1

  公开（公告）日：2022-12-22

  Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.
• [EN] SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF<br/>[FR] INHIBITEURS SÉLECTIFS DE PROTÉINE KINASES ROCK1 ET ROCK2 ET LEURS UTILISATIONS
  申请人：[en]GENOSCO INC.

  公开号：WO2022150381A1

  公开（公告）日：2022-07-14

  The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives, and methods for using the derivatives and/or compositions.