[2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-ethyl]-methyl-amine | 23994-77-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: [2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-ethyl]-methyl-amine
• 英文别名: 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-N-methylethanamine
• CAS: 23994-77-6
• 化学式: C₆H₁₃N₃S
• 分子量: 159.255
• InChiKey: RQLKMRNAXLQCEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Benzene, Pyridine, and Pyridazine Derivatives
  申请人：Huang He Kenneth

  公开号：US20080076813A1

  公开（公告）日：2008-03-27

  Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q 1 , Q 2 , Q 3 , R 3 , and R 4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  本发明涉及公式I的化合物和药用可接受的盐，其中A、Q1、Q2、Q3、R3和R4如本文所定义。公式I的化合物在治疗与细胞增殖相关的疾病和/或病况方面具有用途，如癌症、炎症、关节炎、血管生成等。还公开了包括本发明化合物的药物组合物以及使用这些化合物治疗上述病况的方法。
• Pyrrole, Thiophene, Furan, Imidazole, Oxazole, and Thiazole Derivatives
  申请人：Huang Kenneth He

  公开号：US20090093452A1

  公开（公告）日：2009-04-09

  Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R Q , R 7 , n, Q 2 , Q 3 , Y, and X 1 -X 3 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.