4-Piperidinecarboxylic acid, 1-cyclohexyl-, methyl ester | 1251279-16-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-Piperidinecarboxylic acid, 1-cyclohexyl-, methyl ester
• 英文别名: methyl 1-cyclohexylpiperidine-4-carboxylate
• CAS: 1251279-16-9
• 化学式: C₁₃H₂₃NO₂
• 分子量: 225.33
• InChiKey: IWLRSCGAXQACSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Substituted piperidine and piperazine derivatives as melanocortin-4 receptor modulators
  申请人：Soeberdt Michael

  公开号：US20060241123A1

  公开（公告）日：2006-10-26

  The present invention relates to novel substituted piperidine and piperazine derivatives as melanocortin-4 receptor (MC-4R) modulators. MC-4R agonists of the invention can be used for the treatment of disorders and diseases such as obesity, diabetes, and sexual dysfunction, whereas the MC-4R antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, anxiety and depression. All diseases and disorders where the regulation of the MC-4R is involved can be treated with the compounds of the invention.

  本发明涉及作为黑色素皮质素-4 受体（MC-4R）调节剂的新型取代哌啶和哌嗪衍生物。本发明的 MC-4R 激动剂可用于治疗肥胖、糖尿病和性功能障碍等紊乱和疾病，而 MC-4R 拮抗剂则可用于治疗癌症恶病质、肌肉萎缩、厌食、焦虑和抑郁等紊乱和疾病。所有涉及 MC-4R 调节的疾病都可以用本发明的化合物来治疗。