7HO-MoC^Bz-Tr4 | 123003-60-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 7HO-MoC^Bz-Tr4
• 英文别名: N-(1-(6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide；N-[1-[6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-2-oxopyrimidin-4-yl]benzamide
• CAS: 123003-60-1
• 化学式: C₃₅H₃₂N₄O₄
• 分子量: 572.663
• InChiKey: DMFVVKPXZHMPKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  94.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7HO-MoC^Bz-Tr4 在 三氯氧磷 、 tetrabutylammonium pyrophosphate 、 水 作用下， 以 吡啶 、 乙腈 为溶剂， 反应 1.08h， 生成 [[6-(4-Benzamido-2-oxopyrimidin-1-yl)-4-tritylmorpholin-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
  参考文献：
  名称：

  Synthesis of morpholine nucleoside triphosphates

  摘要：

  Triphosphates of all four ribonucleoside derived morpholine subunits were synthesized and characterized by H-1 and P-31 NMR, UV and mass spectroscopy. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.03.193

文献信息

• Morpholino Nucleic Acid Derivatives
  申请人：Ueda Toshihiro

  公开号：US20130197220A1

  公开（公告）日：2013-08-01

  The present invention provides a useful morpholino nucleic acid derivative for synthesizing a morpholino nucleic acid oligomer. The present invention provides a compound represented by the following general formula (1) or a salt thereof. Here, R 1 represents hydrogen, trityl and so on. R 2 represents an amide or an imine. R 3 represents a hydroxy group which may be protected by trialkylsilyl and so on, or a group represented by the following general formula (5): (wherein X represents O or S, Y represents dialkylamino or alkoxy, and Z represents chlorine).

  本发明提供了一种用于合成吗啉核酸寡聚体的有用吗啉核酸衍生物。本发明提供了以下一般式（1）或其盐所代表的化合物。 在这里，R1代表氢、三苯甲基等。 R2代表酰胺或亚胺。 R3代表一个羟基，可能被三烷基硅基等保护，或者由以下一般式（5）所代表的基团： （其中X代表O或S，Y代表二烷基氨基或烷氧基，Z代表氯）。
• FUNCTIONALLY-MODIFIED OLIGONUCLEOTIDES AND SUBUNITS THEREOF
  申请人：Sarepta Therapeutics, Inc.

  公开号：US20140330006A1

  公开（公告）日：2014-11-06

  Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.

  提供了包含修改的亚单位间连接和/或修改的3'和/或5'-末端基团的功能修饰寡核苷酸类似物。所公开的化合物对于治疗需要抑制蛋白质表达或纠正异常mRNA剪接产物以产生有益治疗效果的疾病是有用的。
• Functionally-modified oligonucleotides and subunits thereof
  申请人：Sarepta Therapeutics, Inc.

  公开号：US10344281B2

  公开（公告）日：2019-07-09

  Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.

  本研究提供了功能修饰的寡核苷酸类似物，这些类似物包含修饰的亚基间连接和/或修饰的 3′和/或 5′末端基团。所公开的化合物可用于治疗抑制蛋白质表达或校正异常 mRNA 剪接产物产生有益治疗效果的疾病。
• Morpholino oligonucleotide manufacturing method
  申请人：AJINOMOTO CO., INC.

  公开号：US10415036B2

  公开（公告）日：2019-09-17

  Using a morpholino nucleotide wherein 5′-hydroxy group or a hydroxy group present on the substituent of the 5′-hydroxy group is protected by a protecting group having an alkyl group having not less than 10 and not more than 300 carbon atoms and/or an alkenyl group having not less than 10 and not more than 300 carbon atoms as a starting material, a method capable of efficiently producing the morpholino oligonucleotide in a high yield by a liquid phase synthesis can be provided.

  以5′-羟基或存在于5′-羟基的取代基上的羟基被具有不小于10个和不大于300个碳原子的烷基和/或具有不小于10个和不大于300个碳原子的烯基的保护基团保护的吗啉核苷酸为起始原料，可以提供一种能够通过液相合成高产率地高效生产吗啉寡核苷酸的方法。
• New oligonucleotide analogues based on morpholine subunits joined by oxalyl diamide tether
  作者：Tatiana V. Abramova、Marat F. Kassakin、Alexander A. Lomzov、Dmitrii V. Pyshnyi、Vladimir N. Silnikov

  DOI：10.1016/j.bioorg.2006.12.003

  日期：2007.6

  We report on the design, synthesis and some of the properties of the new oligonucleotide analogues based on morpholine nucleoside (MorB) subunits joined by an oxalyl diamide tether instead of a phosphate group. The synthetic strategy and oligomer design are optimized to easily obtain target substances without using protective groups. The dimers HOMorU-Ox-NHMorU, HOMorU-Ox-NHMorA, and uracil containing the hexamer HOMorU-(Ox-NHMorU)(5) were synthesized. The structures of all substances were confirmed by H-1, C-13, NMR, and mass spectroscopy. Base stacking interactions in dimers were revealed by CD-spectra data. (C) 2007 Elsevier Inc. All rights reserved.