4-cyclobutylpiperidine | 1081514-03-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-cyclobutylpiperidine
• CAS: 1081514-03-5
• 化学式: C₉H₁₇N
• 分子量: 139.241
• InChiKey: LOOQDRUYWDSXME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-cyclobutylpiperidine 、 对硝基苯磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以94 %的产率得到4-cyclobutyl-1-((4-nitrophenyl)sulfonyl)piperidine
  参考文献：
  名称：

  [EN] LPXH INHIBITORS AS ANTI-INFECTIVE AGENTS
  [FR] INHIBITEURS DE LPXH EN TANT QU'AGENTS ANTI-INFECTIEUX

  摘要：

  The present invention relates to compounds of formula (IIIa), which are suitable for use as anti-infectives, particularly as antibiotics. X1is N or CH. …. is a single or a double bond. When …. is a single bond then X2is selected from the group consisting of CH, N, and N(O), and Y is selected from the group consisting of optionally substituted C3-C10alkyl, optionally substituted C3-C8cycloalkyl, optionally substituted phenyl, and optionally substituted 6-membered heteroaryl. When …. is a double bond then X2is C, and, and Y is selected from the group consisting of optionally substituted C3-C10alkylidene, and optionally substituted C3-C8cycloalkylidene. E is CH, C-OMe or N. Each instance of Z2is independently selected from CH, CF and N. The invention further relates to the use of such compounds in therapeutic applications, as well as pharmaceutical composition comprising such compounds.

  公开号：

  WO2022220725A1

文献信息

• CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA]
  申请人：Phenex Pharmaceuticals AG

  公开号：US20150175562A1

  公开（公告）日：2015-06-25

  The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide or sulfonamide containing cyclic compounds of Formula (1), (1′), (100), (100′), (200) and (200′) and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.

  本发明提供了用于孤儿核受体RORy的调节剂，并通过向需要治疗RORy介导的疾病的人类或哺乳动物注射这些新型RORy调节剂的方法。具体而言，本发明提供了公式（1）、（1'）、（100）、（100'）、（200）和（200'）的含有羧酰胺或磺酰胺的环状化合物及其对映异构体、互异构体、互变异构体、/V-氧化物、溶剂化物和药学上可接受的盐。
• CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED NITROGEN-CONTAINING 5-MEMBERED HETEROCYCLES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR GAMMA
  申请人：PHENEX PHARMACEUTICALS AG

  公开号：US20150344423A1

  公开（公告）日：2015-12-03

  The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide containing cyclic compounds of Formula (1) to Formula (5) and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.

  本发明提供了用于孤儿核受体RORy的调节剂，并通过向需要治疗RORy介导的疾病的人类或哺乳动物施用这些新型RORy调节剂来治疗这些疾病的方法。具体而言，本发明提供了公式（1）至公式（5）的含有羧酰胺的环状化合物及其对映体、二对映异构体、互变异构体、/V-氧化物、溶剂化物和药学上可接受的盐。
• US9458104B2
  申请人：——

  公开号：US9458104B2

  公开（公告）日：2016-10-04