(1-Methylpiperidin-4-YL)methanesulfonyl chloride | 1196156-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (1-Methylpiperidin-4-YL)methanesulfonyl chloride
• CAS: 1196156-73-6
• 化学式: C₇H₁₄ClNO₂S
• mdl: MFCD13190150
• 分子量: 211.71
• InChiKey: AFYXFKSGSRVPNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Substituted piperidine compounds
  申请人：EPIZYME, INC.

  公开号：US10577363B2

  公开（公告）日：2020-03-03

  The present disclosure provides substituted piperidine compounds having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

  本公开提供了具有式（I）的取代哌啶化合物及其药学上可接受的盐和溶液，其中 R1、B、X 和 Z 的定义如说明书所述。本公开还涉及使用式 I 的化合物治疗对 SMYD 蛋白如 SMYD3 或 SMYD2 的阻断有反应的紊乱。本公开的化合物尤其适用于治疗癌症。
• Substituted Piperidine Compounds
  申请人：EPIZYME, INC.

  公开号：US20170362217A1

  公开（公告）日：2017-12-21

  The present disclosure provides substituted piperidine compounds having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R 1 , B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.