4,5-二氢-2-异丁基噻唑 | 26851-79-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 中文名称: 4,5-二氢-2-异丁基噻唑
• 英文名称: 2-(2-Methylpropyl)-2-thiazolin
• 英文别名: 2-isobutyl-4,5-dihydro-thiazole；Thiazole, 4,5-dihydro-2-(2-methylpropyl)-；2-(2-methylpropyl)-4,5-dihydro-1,3-thiazole
• CAS: 26851-79-6
• 化学式: C₇H₁₃NS
• 分子量: 143.253
• InChiKey: SMSJMGHWVFDVCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.7
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2934100090

文献信息

• [EN] TREATMENT OF RESPIRATORY DISEASES WITH AMINO ACID COMPOUNDS<br/>[FR] TRAITEMENT DE MALADIES RESPIRATOIRES AVEC DES COMPOSÉS ACIDES AMINÉS
  申请人：PLIANT THERAPEUTICS INC

  公开号：WO2021225912A1

  公开（公告）日：2021-11-11

  The invention relates to methods of therapy using compounds of formula (I) and formula (II): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (II) and pharmaceutical compositions thereof are integrin inhibitors that are useful in therapy for a condition, for example, caused by or associated with an infectious agent, shock, pancreatitis, or trauma. The condition can include one or more of pulmonary fibrosis associated with rheumatoid arthritis or progressive familial intrahepatic cholestasis (PFIC).

  该发明涉及使用化合物的疗法方法的公式(I)和公式(II)：或其盐，其中R1、R2、R10、R11、R12、R13、R14、R15、R16、q和p如此处所述。公式(II)的化合物及其药物组成物是整合素抑制剂，可用于治疗某种疾病，例如由感染性因子、休克、胰腺炎或创伤引起或相关的疾病。该疾病可能包括与类风湿性关节炎或进行性家族性肝内胆汁淤积症（PFIC）相关的肺纤维化。
• Thermoplastic resin composition
  申请人：NIPPON NYUKAZAI CO., LTD.

  公开号：US10113049B2

  公开（公告）日：2018-10-30

  [Problem] Provided is a thermoplastic resin composition excellent in weather resistance. [Solution] A thermoplastic resin composition containing (a) a thermoplastic resin and (b) an ionically bonded salt represented by the following Chemical Formula (1) or (2): in the Chemical Formulae (1) and (2) above, R1 and R2 each independently represent a substituted or unsubstituted linear, branched, or cyclic alkyl group having from 1 to 30 carbon atoms, a substituted or unsubstituted aryl group having from 6 to 30 carbon atoms, or a substituted or unsubstituted arylalkyl group having from 7 to 31 carbon atoms, A is a linear or branched alkylene group having from 2 to 4 carbon atoms, n represents an integer of 0 to 50, Q1 and Q2 each independently represent at least one kind selected from the group consisting of an ammonium ion, an imidazolium ion, a pyridinium ion, a pyrrolidinium ion, a pyrrolinium ion, a piperidinium ion, a pyrazinium ion, a pyrimidinium ion, a triazolium ion, a triazinium ion, a quinolinium ion, an isoquinolinium ion, an indolinium ion, a quinoxalinium ion, a piperazinium ion, an oxazolinium ion, a thiazolinium ion, and a morpholinium ion.

  [问题]提供一种耐候性优异的热塑性树脂组合物。 [解决方案] 一种热塑性树脂组合物，含有 (a) 热塑性树脂和 (b) 由以下化学式（1）或（2）表示的离子键盐： 在上述化学式（1）和（2）中，R1 和 R2 各自独立地代表具有 1 至 30 个碳原子的取代或 未取代的直链、支链或环状烷基、具有 6 至 30 个碳原子的取代或未取代的芳基或具有 7 至 31 个碳原子的取代或未取代的芳烷基，A 是具有 2 至 4 个碳原子的直链或支链亚烷基，n 代表 0 至 50 的整数、Q1 和 Q2 各自独立地代表至少一种选自以下组成的组的物质：铵离子、咪唑鎓离子、吡啶鎓离子、吡咯烷鎓离子、吡咯烷鎓离子、哌啶鎓离子、吡嗪鎓离子嘧啶鎓离子、三唑鎓离子、三嗪鎓离子、喹啉鎓离子、异喹啉鎓离子、吲哚鎓离子、喹喔啉鎓离子、哌嗪鎓离子、噁唑啉鎓离子、噻唑啉鎓离子和吗啉鎓离子。
• THERMOPLASTIC RESIN COMPOSITION
  申请人：NIPPON NYUKAZAI CO., LTD.

  公开号：US20150329698A1

  公开（公告）日：2015-11-19

  [Problem] Provided is a thermoplastic resin composition excellent in weather resistance. [Solution] A thermoplastic resin composition containing (a) a thermoplastic resin and (b) an ionically bonded salt represented by the following Chemical Formula (1) or (2): in the Chemical Formulae (1) and (2) above, R 1 and R 2 each independently represent a substituted or unsubstituted linear, branched, or cyclic alkyl group having from 1 to 30 carbon atoms, a substituted or unsubstituted aryl group having from 6 to 30 carbon atoms, or a substituted or unsubstituted arylalkyl group having from 7 to 31 carbon atoms, A is a linear or branched alkylene group having from 2 to 4 carbon atoms, n represents an integer of 0 to 50, Q1 and Q2 each independently represent at least one kind selected from the group consisting of an ammonium ion, an imidazolium ion, a pyridinium ion, a pyrrolidinium ion, a pyrrolinium ion, a piperidinium ion, a pyrazinium ion, a pyrimidinium ion, a triazolium ion, a triazinium ion, a quinolinium ion, an isoquinolinium ion, an indolinium ion, a quinoxalinium ion, a piperazinium ion, an oxazolinium ion, a thiazolinium ion, and a morpholinium ion.