ethyl 2-(2-tritylamino-4-thiazolyl)-2-ethoxy iminoacetate | 344344-42-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: ethyl 2-(2-tritylamino-4-thiazolyl)-2-ethoxy iminoacetate
• 英文别名: Ethyl 2-(2-tritylamino-4-thiazolyl)-2-ethoxyiminoacetate；ethyl 2-ethoxyimino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetate
• CAS: 344344-42-9
• 化学式: C₂₈H₂₇N₃O₃S
• 分子量: 485.607
• InChiKey: YWOXLAICRFDEIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  三苯基氯甲烷 、 syn-Ethyl-2-ethoxy-imino-2-(2-amino-1,3-thiazol-4-yl)acetat 、 N,N-二甲基甲酰胺 、 盐酸 在 C.I.颜料红53：1 、 盐酸 、 水 、 二氯甲烷 作用下， 以 三乙胺 、 二氯甲烷 为溶剂， 反应 3.5h， 以to obtain 7.89 g of raw ethyl 2-(2-tritylamino-4-thiazolyl)-2-ethoxyiminoacetate having a syn configuration的产率得到ethyl 2-(2-tritylamino-4-thiazolyl)-2-ethoxy iminoacetate
  参考文献：
  名称：

  Novel 3-acetoxymethyl-7-(iminoacetamido)-cephalosporanic acid derivatives

  摘要：

  化合物的公式为##STR1##其中R从氢和易于通过酸水解或氢解除去的基团中选择，R'从1至4个碳原子的烷基，2至4个碳原子的烯基和炔基以及易于通过酸水解或氢解除去的基团中选择，A从氢，碱金属和碱土金属或镁的等效物以及有机胺碱基中选择，但当R'为易于通过酸水解或氢解除去的基团时，R也是如此，当R'为氢时，R也是氢，波浪线表示OR'基团可以处于两种可能的同步或反向位置，具有抗生素活性和制备它们的过程。

  公开号：

  US04376203A1

文献信息

• 3-Acetoxymethyl-7-(iminoacetamido)-cephalosporanic acid derivatives
  申请人：Roussel Uclaf

  公开号：US04152432A1

  公开（公告）日：1979-05-01

  Compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and groups easily removable by acid hydrolysis or hydrogenolysis, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl and alkynyl of 2 to 4 carbon atoms and groups easily removable by acid hydrolysis or hydrogenolysis, A is selected from the group consisting of hydrogen, alkali metal and equivalents of an alkaline earth metal or magnesium and an organic amine base with the proviso that when R' is a group easily removable by acid hydrolysis or hydrogenolysis, R is also and when R' is hydrogen, R also is hydrogen and the wavy line means the OR' group may be in either one of the two possible syn or anti positions having antibiotic activity and process for their preparation.

  化合物的公式为：##STR1## 其中R选自氢和易于通过酸水解或氢解去除的基团，R'选自1至4个碳原子的烷基、2至4个碳原子的烯基和炔基以及易于通过酸水解或氢解去除的基团，A选自氢、碱金属和碱土金属或镁的等效物以及有机胺碱，但当R'是易于通过酸水解或氢解去除的基团时，R也是如此；当R'是氢时，R也是氢。其中波浪线表示OR'基团可以处于两种可能的同步或反向位置。该化合物具有抗生素活性，以及其制备方法。
• 3-Acetoxymethyl-7-(hydroxyiminoacetamido)-cephalosporanic acid
  申请人：Roussel Uclaf

  公开号：US04283396A1

  公开（公告）日：1981-08-11

  Compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and groups easily removable by acid hydrolysis or hydrogenolysis, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl and alkynyl of 2 to 4 carbon atoms and groups easily removable by acid hydrolysis or hydrogenolysis, A is selected from the group consisting of hydrogen, alkali metal and equivalents of an alkaline earth metal or magnesium and an organic amine base with the proviso that when R' is a group easily removable by acid hydrolysis or hydrogenolysis, R is also and when R' is hydrogen, R also is hydrogen and the wavy line means the OR' group may be in either one of the two possible syn or anti positions having antibiotic activity and process for their preparation.

  化合物的公式为##STR1##其中R是从氢和易于通过酸水解或氢解去除的基团中选择的，R'是从1到4个碳原子的烷基，2到4个碳原子的烯基和炔基以及易于通过酸水解或氢解去除的基团中选择的，A是从氢，碱金属和等价的碱土金属或镁以及有机胺基中选择的，但是当R'是易于通过酸水解或氢解去除的基团时，R也是如此，当R'是氢时，R也是氢，波浪线表示OR'基团可以位于两个可能的同步或反向位置中具有抗生素活性及其制备方法。
• Aminothiazolyl acetic acid derivatives
  申请人：Roussel Uclaf

  公开号：US04843164A1

  公开（公告）日：1989-06-27

  Compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and groups easily removable by acid hydrolysis or hydrogenolysis, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl and alkynyl of 2 to 4 carbon atoms and groups easily removable by acid hydrolysis or hydrogenolysis, A is selected from the group consisting of hydrogen, alkali metal and equivalents of an alkaline earth metal or magnesium and an organic amine base with the proviso that when R' is a group easily removable by acid hydrolysis or hydrogenolysis, R is also and when R' is hydrogen, R also is hydrogen and the wavy line means the OR' group may be in either one of the two possible syn or anti positions having antibiotic activity and process for their preparation.

  化合物的公式为##STR1##其中R选自氢和易于通过酸水解或氢解去除的基团，R'选自1至4个碳原子的烷基，2至4个碳原子的烯基和炔基以及易于通过酸水解或氢解去除的基团，A选自氢，碱金属和等量的碱土金属或镁以及有机胺碱，但当R'为易于通过酸水解或氢解去除的基团时，R也是如此，当R'为氢时，R也是氢，而波浪线表示OR'基团可以处于两种可能的同步或反式位置，具有抗生素活性和制备它们的过程。
• 3-acetoxymethyl-7-(iminoacetamideo)-cephalosporanic acid
  申请人：Roussel UCLAF

  公开号：US05336776A1

  公开（公告）日：1994-08-09

  Thiazole intermediates for Cephalosporing are prepared.

  制备头孢菌素的噻唑中间体。
• 3-acetoxymethyl-7-(iminoacetamino)-cephalosporanic acid derivatives
  申请人：Roussel Uclaf

  公开号：US05103012A1

  公开（公告）日：1992-04-07

  Compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and groups easily removable by acid hydrolysis or hydrogenolysis, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl and alkynyl of 2 to 4 carbon atoms and groups easily removable by acid hydrolysis or hydrogenolysis, A is selected from the group consisting of hydrogen, alkali metal and equivalents of an alkaline earth metal or magnesium and an organic amine base with the proviso that when R' is a group easily removable by acid hydrolysis or hydrogenolysis, R is also and when R' is hydrogen, R also is hydrogen and the wavy line means the OR' group may be in either one of the two possible syn or anti positions having antibiotic activity and process for their preparation.

  化合物的公式为##STR1##其中R从由氢和易于通过酸水解或氢解去除的基团中选择，R'从由1至4个碳原子的烷基，2至4个碳原子的烯基和炔基以及易于通过酸水解或氢解去除的基团中选择，A从氢，碱金属和碱土金属或镁的等效物以及有机胺基中选择，但是当R'是易于通过酸水解或氢解去除的基团时，R也是如此，当R'为氢时，R也是氢，波浪线表示OR'基团可以处于两个可能的同构或异构位置，具有抗生素活性和制备它们的过程。