2-Aza-bicyclo[2.2.1]heptan-5-ol | 1365570-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Aza-bicyclo[2.2.1]heptan-5-ol
• 英文别名: 2-azabicyclo[2.2.1]heptan-5-ol
• CAS: 1365570-43-9
• 化学式: C₆H₁₁NO
• 分子量: 113.16
• InChiKey: XQDSUPZEXMHXIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] INHIBITORS OF MUTANT FORMS OF EGFR<br/>[FR] INHIBITEURS DE FORMES MUTANTES DE L'EGFR
  申请人：BLUEPRINT MEDICINES CORP

  公开号：WO2021133809A1

  公开（公告）日：2021-07-01

  The present disclosure provides a compound represented by structural formula (I) : or a pharmaceutically acceptable salt thereof useful for treating a cancer.

  本公开提供了一种由结构公式（I）表示的化合物：或其药用可接受的盐，用于治疗癌症。
• [EN] 2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE 2,4-DIAMINOPYRIMIDINE EN TANT QU'INHIBITEURS DE PROTÉINE KINASES
  申请人：AURIGENE DISCOVERY TECH LTD

  公开号：WO2012059932A1

  公开（公告）日：2012-05-10

  The present invention relates to novel pyrimide derivatives of formula (I): that are useful as kinase inhibitors. More particularly, the present invention relates to novel pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders.

  本发明涉及一种新型的式（I）的嘧啶衍生物，其作为激酶抑制剂具有用途。更具体地，本发明涉及新型嘧啶化合物、其制备方法、含有这些化合物的药物组合物以及这些化合物在治疗增殖性疾病中的用途。
• Heterocyclic compounds as immunomodulators
  申请人：Incyte Corporation

  公开号：US10308644B2

  公开（公告）日：2019-06-04

  Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

  本发明公开了式（I）化合物、将这些化合物用作免疫调节剂的方法以及包含这些化合物的药物组合物。这些化合物可用于治疗、预防或改善癌症或感染等疾病或紊乱。
• BENZOOXAZOLE DERIVATIVES AS IMMUNOMODULATORS
  申请人：Incyte Corporation

  公开号：EP3558985A1

  公开（公告）日：2019-10-30
• HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
  申请人：Incyte Corporation

  公开号：US20180179197A1

  公开（公告）日：2018-06-28

  Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.