5-Methanesulfonylpent-1-yne | 1039433-05-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 5-Methanesulfonylpent-1-yne
• 英文别名: 5-methylsulfonylpent-1-yne
• CAS: 1039433-05-0
• 化学式: C₆H₁₀O₂S
• 分子量: 146.21
• InChiKey: XACDCVZZCVFSDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS<br/>[FR] COMPOSÉS ANTI-HYPERCHOLESTÉROLÉMIQUES
  申请人：MERCK SHARP & DOHME

  公开号：WO2010056788A1

  公开（公告）日：2010-05-20

  One object of the instant invention is to provide novel cholesterol absorption inhibitors of Formula I or pharmaceutically acceptable salts thereof.

  本发明的一个目标是提供式I的新型胆固醇吸收抑制剂或其药用可接受的盐。
• Anti-hypercholesterolemic biaryl azetidinone compounds
  申请人：Morriello Gregori J.

  公开号：US20080280836A1

  公开（公告）日：2008-11-13

  This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R 12 is an alkyl, alkeny or alkynyl group mono- or poly-substituted with —OH, —COOH or a combination of —OH and —COOH, and R 9 contains an alkyl, alkeny or alkynyl group substituted with a heterocyclic ring, amino or sulfonyl. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.

  这项发明提供了化学式I的胆固醇吸收抑制剂及其药用盐，其中R12是一个烷基、烯烃或炔烃基，单取代或多取代于—OH、—COOH或—OH和—COOH的组合，而R9含有一个被杂环环、氨基或磺酰基取代的烷基、烯烃或炔烃基。这些化合物对降低血浆胆固醇水平，特别是LDL胆固醇，以及治疗动脉粥样硬化和预防动脉粥样硬化疾病事件具有用处。
• ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS
  申请人：DeVita Robert J.

  公开号：US20100035857A1

  公开（公告）日：2010-02-11

  This invention provides cholesterol absorption inhibitors of Formula I:I and the pharmaceutically acceptable salts thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.

  本发明提供了I式的胆固醇吸收抑制剂及其药学上可接受的盐。这些化合物可用于降低血浆胆固醇水平，特别是低密度脂蛋白胆固醇，并用于治疗和预防动脉粥样硬化和动脉粥样硬化性疾病事件。
• Therapeutic Compounds
  申请人：Katz Jason

  公开号：US20110207711A1

  公开（公告）日：2011-08-25

  The present invention relates to pyrazolopyridines and imidazopyridines which are inhibitors of the kinase PDK1 and are thus useful for the treatment of myeloproliferative disorders or cancer. The compounds are also useful as inhibitors of other kinases such as FGFR3, NTRK3, RP-S6K and WEE1. Furthermore, the present compounds also selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease.

  本发明涉及一种抑制激酶PDK1的吡唑吡啶和咪唑吡啶化合物，因此可用于治疗骨髓增生性疾病或癌症。这些化合物也可用作其他激酶的抑制剂，例如FGFR3、NTRK3、RP-S6K和WEE1。此外，本化合物还具有选择性抑制微管亲和力调节激酶（MARK）的作用，因此可用于治疗或预防阿尔茨海默病。
• NONAQUEOUS ELECTROLYTE SOLUTION, ELECTROCHEMICAL ELEMENT USING SAME, AND 1,2-DIOXYPROPANE COMPOUND USED IN SAME
  申请人：Miyoshi Kazuhiro

  公开号：US20130004862A1

  公开（公告）日：2013-01-03

  An object of the present invention is to provide a nonaqueous electrolytic solution capable of improving low-temperature load characteristics after high temperature charging storage, an electrochemical element using it, and a 1,2-dioxypropane compound used for it. The nonaqueous electrolytic solution of the present invention comprises an electrolyte salt dissolved in a nonaqueous solvent, and contains a 1,2-dioxypropane compound represented by the above-mentioned general formula (I). (wherein R 1 and R 2 each represent a hydrogen atom, or an alkyl group having from 1 to 6 carbon atoms; X 1 represents a group selected from —S(═O)—, —S(═O) 2 —, —C(═O)—, —CR 3 R 4 —, —P(═O)(OR 5 )— and —SiR 6 R 7 —; R 3 and R 4 each represent a hydrogen atom, or an alkyl group having from 1 to 6 carbon atoms; R 5 to R 7 each represent an alkyl group having from 1 to 6 carbon atoms. Y 1 represents an alkylsulfinyl group, an alkenylsulfinyl group, an alkynylsulfinyl group, an arylsulfinyl group, an alkylsulfonyl group, an alkenylsulfonyl group, an alkynylsulfonyl group, or an arylsulfonyl group; Z 1 represents a hydrogen atom, an alkyl group, an alkylsulfinylmethyl group, an alkenylsulfinylmethyl group, an alkynylsulfinylmethyl group, an arylsulfinylmethyl group, an alkylsulfonylmethyl group, an alkenylsulfonylmethyl group, an alkynylsulfonylmethyl group, or an arylsulfonylmethyl group; provided that at least one hydrogen atom on the carbon atom of X 1 , Y 1 and Z 1 may be substituted with a halogen atom).

  本发明的目的是提供一种非水电解质溶液，能够在高温充电储存后改善低温负载特性，以及使用它的电化学元件和用于它的1,2-二氧丙烷化合物。本发明的非水电解质溶液包括溶解在非水溶剂中的电解质盐，并含有由上述通式(I)所表示的1,2-二氧丙烷化合物。（其中，R1和R2各代表氢原子或具有1至6个碳原子的烷基；X1代表从—S(═O)—、—S(═O)2—、—C(═O)—、—CR3R4—、—P(═O)(OR5)—和—SiR6R7—中选择的一组基团；R3和R4各代表氢原子或具有1至6个碳原子的烷基；R5至R7各代表具有1至6个碳原子的烷基。Y1代表烷基亚磺酰基、烯基亚磺酰基、炔基亚磺酰基、芳基亚磺酰基、烷基磺酰基、烯基磺酰基、炔基磺酰基或芳基磺酰基；Z1代表氢原子、烷基、烷基亚磺酰甲基、烯基亚磺酰甲基、炔基亚磺酰甲基、芳基亚磺酰甲基、烷基磺酰甲基、烯基磺酰甲基、炔基磺酰甲基或芳基磺酰甲基；但至少在X1、Y1和Z1的碳原子上的一个氢原子可以被卤素原子取代。）