1-Aethyl-3-methyl-2-piperidon | 90204-44-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Aethyl-3-methyl-2-piperidon
• 英文别名: 3-Methyl-1-ethyl-piperidon-(2)；1-ethyl-3-methyl-piperidin-2-one；1-Ethyl-3-methylpiperidin-2-one
• CAS: 90204-44-7
• 化学式: C₈H₁₅NO
• 分子量: 141.213
• InChiKey: RAHGLYVNKLPKAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
  申请人：GILEAD APOLLO LLC

  公开号：WO2017075056A1

  公开（公告）日：2017-05-04

  The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

  本发明提供了化合物I和II，这些化合物可用作乙酰辅酶A羧化酶（ACC）的抑制剂，以及它们的组合物和使用方法。
• Sample preparation, processing and analysis systems
  申请人：INTEGENX INC.

  公开号：US10865440B2

  公开（公告）日：2020-12-15

  This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.

  本公开提供了一种集成的自动采样-应答系统，该系统可从包含生物材料的样本开始，在两小时内生成基因图谱。在某些实施方案中，生物材料是 DNA，基因图谱涉及确定受试者一个或多个位点（如基因位点）上的等位基因，例如，STR（短串联重复）图谱，例如 CODIS 系统中使用的图谱。该系统可执行多项操作，包括：(a) 提取和分离核酸；(b) 扩增选定位点（如基因位点）的核苷酸序列；(c) 检测和分析扩增产物。这些操作可在一个由多个集成模块组成的系统中进行，包括分析物制备模块、检测和分析模块以及控制模块。
• SAMPLE PREPARATION, PROCESSING AND ANALYSIS SYSTEMS
  申请人：INTEGENX INC.

  公开号：US20150024436A1

  公开（公告）日：2015-01-22

  This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
• ACC INHIBITORS AND USES THEREOF
  申请人：Gilead Apollo, LLC

  公开号：US20170145028A1

  公开（公告）日：2017-05-25

  The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
• Sample Preparation, Processing and Analysis Systems
  申请人：Integenx Inc.

  公开号：US20210277445A1

  公开（公告）日：2021-09-09

  This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.