cis-5-nitro-6-(3-trifluoromethoxyphenyl)-piperidin-2-one | 147249-31-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: cis-5-nitro-6-(3-trifluoromethoxyphenyl)-piperidin-2-one
• 英文别名: rel-(5R,6R)-5-Nitro-6-[3-(trifluoromethoxy)phenyl]-2-piperidinone；(5S,6S)-5-nitro-6-[3-(trifluoromethoxy)phenyl]piperidin-2-one
• CAS: 147249-31-8
• 化学式: C₁₂H₁₁F₃N₂O₄
• 分子量: 304.226
• InChiKey: DZGJFCHDJTUUCE-ONGXEEELSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
  申请人：——

  公开号：US20020035147A1

  公开（公告）日：2002-03-21

  The present invention relates to methods of treating various CNS and other disorders by adminstering fluoroalkoxybenzylamino derivatives of nitrogen containing heterocyclic compounds, and specifically, by administering compounds of the formula 1 wherein Q, X 1 , X 2 and X 3 are as defined below, and their pharmaceutically acceptable salts.

  本发明涉及通过给予含氮杂环化合物的氟烷氧基苄胺衍生物来治疗各种中枢神经系统和其他疾病的方法，具体地，通过给予以下公式中的化合物来治疗： 1 其中Q、X 1 、X 2 和X 3 如下所定义，并且它们的药用盐。
• [EN] FLUOROALKOXYBENZYLAMINO DERIVATIVES OF NITROGEN CONTAINING HETEROCYCLES
  申请人：PFIZER INC.

  公开号：WO1993000331A1

  公开（公告）日：1993-01-07

  (EN) The present invention relates to novel fluoroalkoxybenzylamino derivatives of nitrogen containing heterocyclic compounds, and specifically, to compounds of formula (I) wherein Q, X1, X2 and X3 are as defined below. These novel compounds are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.(FR) La présente invention à trait à de nouveaux dérivés fluoroalcoxybenzylamino de composés hétérocycliques contenant de l'azote et, spécialement, à des composés de la formule (I) dans laquelle Q, X1, X2 et X3 ont la notation ci-définie. Ces nouveaux composés sont utiles pour le traitement des affections inflammatoires et des troubles du système nerveux central ainsi que pour d'autres affections.

  该发明涉及一种新型含氮杂环化合物的氟烷氧基苯基氨基衍生物，具体而言，涉及式（I）中Q、X1、X2和X3定义如下的化合物。这些新化合物在治疗炎症和中枢神经系统疾病以及其他疾病方面具有用途。
• Fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
  申请人：Lowe Adams John

  公开号：US20050256162A1

  公开（公告）日：2005-11-17

  The present invention relates to novel fluoroalkoxybenzylamino derivatives of nitrogen containing heterocyclic compounds, and specifically, to compounds of the formula wherein Q, X 1 , X 2 and X 3 are as defined below. These novel compounds are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.

  本发明涉及一种新型含氮杂环化合物的氟烷氧基苯基氨基衍生物，具体地，涉及以下式子的化合物：其中Q、X1、X2和X3如下所定义。这些新型化合物在治疗炎症和中枢神经系统疾病以及其他疾病方面具有用途。
• Fluoroalkyoxybenzylamino derivatives of nitrogen containing heterocycles
  申请人：——

  公开号：US20030199540A1

  公开（公告）日：2003-10-23

  The present invention relates to novel fluoroalkoxybenzylamino derivatives of nitrogen containing heterocyclic compounds, and specifically, to compounds of the formula 1 wherein Q, X 1 , X 2 and X 3 are as defined below. These novel compounds are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.

  本发明涉及一种新型含氮杂环化合物的氟烷氧基苯基氨基衍生物，具体地，涉及式1的化合物，其中Q、X1、X2和X3如下所定义。这些新型化合物在治疗炎症和中枢神经系统疾病以及其他疾病方面是有用的。
• Use of fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles as substance P receptor antagonists
  申请人：Pfizer Products Inc.

  公开号：EP1172106A2

  公开（公告）日：2002-01-16

  The present invention relates to methods of treating various CNS and other disorders by adminstering fluoroalkoxybenzylamino derivatives of nitrogen containing heterocyclic compounds, and specifically, by administering compounds of the formula    wherein Q, X1, X2 and X3 are as defined below, and their pharmaceutically acceptable salts.

  本发明涉及通过施用含氮杂环化合物的氟烷氧基苄基氨基衍生物来治疗各种中枢神经系统疾病和其他疾病的方法，特别是通过施用式中的化合物 其中 Q、X1、X2 和 X3 如下文所定义，以及它们的药学上可接受的盐类。