| 1333168-12-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 1333168-12-9
• 化学式: C₃₅H₃₆N₄O₇S
• 分子量: 656.759
• InChiKey: IGSDTVPWVNNROO-PMFUCWTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.39
• 重原子数：
  47.0
• 可旋转键数：
  11.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  138.73
• 氢给体数：
  3.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  在 二叔丁基二氯化锡 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 生成
  参考文献：
  名称：

  Emissive RNA Alphabet

  摘要：

  A fluorescent ribonucleoside alphabet consisting of highly emissive purine ((th)A, (th)G) and pyrimidine (U-th, C-th) analogues, all derived from thieno[3,4-d]pyrimidine as the heterocyclic nucleus, is described. Structural and biophysical analyses demonstrated that the emissive analogues are faithful isomorphic nucleoside surrogates. Photophysical analysis established that the nucleosides offer highly desirable qualities, including visible emission, high quantum yield, and responsiveness to environmental perturbations, traits entirely lacking in their native counterparts.

  DOI：

  10.1021/ja206095a
• 作为产物：
  描述：

  N'-[7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-oxo-3H-thieno[3,4-d]pyrimidin-2-yl]-N,N-dimethylmethanimidamide 、 4,4'-双甲氧基三苯甲基氯 以 吡啶 为溶剂， 反应 3.0h， 以70%的产率得到
  参考文献：
  名称：

  Emissive RNA Alphabet

  摘要：

  A fluorescent ribonucleoside alphabet consisting of highly emissive purine ((th)A, (th)G) and pyrimidine (U-th, C-th) analogues, all derived from thieno[3,4-d]pyrimidine as the heterocyclic nucleus, is described. Structural and biophysical analyses demonstrated that the emissive analogues are faithful isomorphic nucleoside surrogates. Photophysical analysis established that the nucleosides offer highly desirable qualities, including visible emission, high quantum yield, and responsiveness to environmental perturbations, traits entirely lacking in their native counterparts.

  DOI：

  10.1021/ja206095a

文献信息

• Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides c ^th GAMP
  作者：Simon Veth、Adrian Fuchs、Dilara Özdemir、Clemens Dialer、David Jan Drexler、Fabian Knechtel、Gregor Witte、Karl‐Peter Hopfner、Thomas Carell、Evelyn Ploetz

  DOI：10.1002/cbic.202200005

  日期：2022.4.20

  The cyclic dinucleotide (CDN) 2’3’-cGAMP is an essential second messenger for the innate immune system of mammals. The organic synthesis of an intrinsically fluorescent mimic provided large quantities for cell feeding studies, examination of biological activity and two-photon excitation microscopy.

  环状二核苷酸 (CDN) 2'3'-cGAMP 是哺乳动物先天免疫系统必不可少的第二信使。固有荧光模拟物的有机合成为细胞喂养研究、生物活性检查和双光子激发显微镜提供了大量的材料。