Methyl (2-((R)-(3-chlorophenyl)((R)-1-(((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propyl)carbamoyl)piperidin-3-yl)methoxy)ethyl)carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Methyl (2-((R)-(3-chlorophenyl)((R)-1-(((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propyl)carbamoyl)piperidin-3-yl)methoxy)ethyl)carbamate
• 英文别名: methyl N-[2-[(3-chlorophenyl)-[1-[[2-(methylamino)-3-(oxan-3-yl)propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate
• 化学式: C₂₆H₄₁ClN₄O₅
• 分子量: 525.1
• InChiKey: NXWASIVXQMMPLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  36
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Renin Inhibitors
  申请人：Baldwin John J.

  公开号：US20090312369A1

  公开（公告）日：2009-12-17

  The present invention is directed to aspartic protease inhibitors represented by the following structural formula (I), or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the aspartic protease inhibitors of Structural Formula (I). Methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using these aspartic protease inhibitors are also disclosed.

  本发明涉及以下结构式(I)所表示的天冬氨酸蛋白酶抑制剂，或其药学上可接受的盐。本发明还涉及包括结构式(I)的天冬氨酸蛋白酶抑制剂的制药组合物。本发明还公开了用这些天冬氨酸蛋白酶抑制剂拮抗一个或多个需要治疗的天冬氨酸蛋白酶的方法，以及用这些天冬氨酸蛋白酶抑制剂治疗一个天冬氨酸蛋白酶介导的疾病的方法。
• PIPERIDINE RENIN INHIBITORS
  申请人：Baldwin John J.

  公开号：US20120225906A1

  公开（公告）日：2012-09-06

  The present invention is directed to aspartic protease inhibitors represented by the following structural formula: or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the aspartic protease inhibitors of Structural Formula (I). Methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using these aspartic protease inhibitors are also disclosed.

  本发明涉及以下结构式所表示的天冬氨酸蛋白酶抑制剂或其药学上可接受的盐： 本发明还涉及包含结构式（I）的天冬氨酸蛋白酶抑制剂的制药组合物。还公开了通过使用这些天冬氨酸蛋白酶抑制剂拮抗一个或多个需要的天冬氨酸蛋白酶的方法，以及治疗一个天冬氨酸蛋白酶介导的疾病的方法。
• RENIN INHIBITORS
  申请人：Vitae Pharmaceuticals, Inc.

  公开号：EP2074108B1

  公开（公告）日：2012-11-21
• US8198453B2
  申请人：——

  公开号：US8198453B2

  公开（公告）日：2012-06-12
• US8580823B2
  申请人：——

  公开号：US8580823B2

  公开（公告）日：2013-11-12