| 188796-21-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 188796-21-6
• 化学式: C₅₈H₆₃N₅O₁₁Si
• 分子量: 1034.25
• InChiKey: XDHGXUVCPWLCAO-RZEXOQFNSA-N

反应信息

• 作为反应物：
  描述：

  在 四丁基氟化铵 作用下， 反应 1.5h， 以96%的产率得到3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-carboxylic acid [2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-amide
  参考文献：
  名称：

  Replacement of the phosphodiester linkage in oligonucleotides by an amide: Effect of backbone length on duplex stability with RNA complement

  摘要：

  Five dimers containing amide linkages instead of the natural phosphodiester linkage were synthesized and incorporated into oligonucleotides. The length of the amide backbone was varied. The hybridization properties of the modified oligonucleotides with RNA complements and their conformational analysis are described and compared to previously reported amide containing oligonucleotides. In addition, the synthesis of a thioamide phosphoramidite dimer is reported. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00037-1
• 作为产物：
  描述：

  (2S,3S,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydrofuran-2-carboxylic acid 、 1-{(2R,4R,5S)-4-Aminomethyl-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 在 1-羟基苯并三唑 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 7.5h， 以90%的产率得到
  参考文献：
  名称：

  Replacement of the phosphodiester linkage in oligonucleotides by an amide: Effect of backbone length on duplex stability with RNA complement

  摘要：

  Five dimers containing amide linkages instead of the natural phosphodiester linkage were synthesized and incorporated into oligonucleotides. The length of the amide backbone was varied. The hybridization properties of the modified oligonucleotides with RNA complements and their conformational analysis are described and compared to previously reported amide containing oligonucleotides. In addition, the synthesis of a thioamide phosphoramidite dimer is reported. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00037-1