3-benzyl-2,6-bis(4-fluorophenyl)piperidin-4-one | 1438383-73-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-benzyl-2,6-bis(4-fluorophenyl)piperidin-4-one
• CAS: 1438383-73-3
• 化学式: C₂₄H₂₁F₂NO
• 分子量: 377.434
• InChiKey: RDGQTQKRDFAVFO-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  苄基丙酮 、 对氟苯甲醛 在 ammonium acetate 作用下， 以 乙醇 为溶剂， 反应 0.17h， 以22.54%的产率得到3-benzyl-2,6-bis(4-fluorophenyl)piperidin-4-one
  参考文献：
  名称：

  Novel 3-benzyl-2,6-diarylpiperidin-4-one derivatives: syntheses, characterization, and antimicrobial profile

  摘要：

  The study was aimed at the syntheses and evaluation of a series of novel 3-benzyl-2,6-diarylpiperidine-4-ones. The newly synthesized compounds were characterized by elemental analysis, infrared, H-1 NMR, C-13 NMR, and mass spectral analyses. These compounds were screened for their inhibiting potential against various bacterial and fungal strains. The antimicrobial activity was performed against four Gram positive bacteria (S. aureus, B. subtilis, B. pumilus, and M. luteus), three Gram negative bacteria (P. aeruginosa, P. fluorescens, and E. coli), and two fungal strains (A. niger and P. chrysogenum) by cup-plate method and tube assay method. The results reveal that some of these compounds exhibited remarkable activity against the selected bacterial and fungal strains, with MIC values as low as 50 mu g/mL. Interestingly, all the compounds exhibited better antifungal activity than antibacterial activity. Thus, it can be concluded that 3-benzyl-2,6-diarylpiperidine-4-ones may exhibit potent antifungal activity.

  DOI：

  10.1007/s00044-013-0624-2