Propane-2-sulfonic acid piperidin-4-ylamide | 577778-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Propane-2-sulfonic acid piperidin-4-ylamide
• 英文别名: N-piperidin-4-ylpropane-2-sulfonamide
• CAS: 577778-43-9
• 化学式: C₈H₁₈N₂O₂S
• 分子量: 206.309
• InChiKey: JZBGMQLTTFPCOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  丙酰氯 、 Propane-2-sulfonic acid piperidin-4-ylamide 在 碳酸氢钠 作用下， 以 氯仿 为溶剂， 以42%的产率得到Propane-2-sulfonic acid (1-propionyl-piperidin-4-yl)-amide
  参考文献：
  名称：

  4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs

  摘要：

  Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-amino-piperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9. active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00437-2
• 作为产物：
  描述：

  Propane-2-sulfonic acid (1-benzyl-piperidin-4-yl)-amide 在 palladium on activated charcoal 、 甲酸铵 作用下， 以 甲醇 为溶剂， 以50%的产率得到Propane-2-sulfonic acid piperidin-4-ylamide
  参考文献：
  名称：

  4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs

  摘要：

  Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-amino-piperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9. active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00437-2

文献信息

• NPYY5 ANTAGONISTS
  申请人：SHIONOGI & CO., LTD.

  公开号：EP1249233B9

  公开（公告）日：2009-08-05
• DERIVATIVES OF BETA-AMINO ACID AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS
  申请人：RANBAXY LABORATORIES, LTD.

  公开号：EP1973918A2

  公开（公告）日：2008-10-01
• NPYY5 antagonists
  申请人：Shionogi&Co., Ltd.

  公开号：EP2014285B1

  公开（公告）日：2010-05-05
• [EN] DERIVATIVES OF BETA-AMINO ACID AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS<br/>[FR] DÉRIVÉS DE BÊTA-AMINOACIDES COMME INHIBITEURS DE LA DIPEPTIDYLPEPTIDASE IV
  申请人：RANBAXY LAB LTD

  公开号：WO2007077508A2

  公开（公告）日：2007-07-12

  [EN] The present invention relates to ß-amino acid derivatives as dipeptidyl peptidase- IV inhibitors and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.
  [FR] La présente invention concerne des dérivés de ß-aminoacides utilisés comme inhibiteurs de la dipeptidylpeptidase IV, ainsi que les procédés de synthèse de ces inhibiteurs. La présente invention concerne également des compositions pharmacologiques contenant les composés de la présente invention, et des procédés de traitement du diabète, notamment du diabète de type 2, ainsi que du prédiabète, de la dyslipidémie diabétique, de l'acidose métabolique, de la cétose, des troubles de la satiété et de l'obésité. Ces inhibiteurs peuvent également être utilisés pour traiter des affections qui se manifestent par divers troubles métaboliques, neurologiques, anti-inflammatoires et auto-immuns telles que la maladie inflammatoire, la sclérose en plaques, la polyarthrite rhumatoïde ; des troubles viraux, cancéreux et gastro-intestinaux. Les composés de la présente invention peuvent également être utilisés pour le traitement de l'infertilité due au syndrome de l'ovaire polykystique.
• 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs
  作者：Dina Manetti、Elisabetta Martini、Carla Ghelardini、Silvia Dei、Nicoletta Galeotti、Luca Guandalini、Maria Novella Romanelli、Serena Scapecchi、Elisabetta Teodori、Alessandro Bartolini、Fulvio Gualtieri

  DOI：10.1016/s0960-894x(03)00437-2

  日期：2003.7

  Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-amino-piperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9. active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease. (C) 2003 Elsevier Science Ltd. All rights reserved.