(2S)-6-methylimidazo[2,1-b]thiazole-5-carboxylic acid [1-(2-amino-5-m-tolylthiazole-4-carbonyl)azetidin-2-ylmethyl]amide | 1007874-29-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并噻唑类
• 英文名称: (2S)-6-methylimidazo[2,1-b]thiazole-5-carboxylic acid [1-(2-amino-5-m-tolylthiazole-4-carbonyl)azetidin-2-ylmethyl]amide
• 英文别名: N-[[(2S)-1-[2-amino-5-(3-methylphenyl)-1,3-thiazole-4-carbonyl]azetidin-2-yl]methyl]-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide
• CAS: 1007874-29-4
• 化学式: C₂₂H₂₂N₆O₂S₂
• 分子量: 466.588
• InChiKey: KDGXBBVQMXWUAP-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  162
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• POLYESTER OLIGOMERS, METHODS OF MAKING, AND THERMOSETTING COMPOSITIONS FORMED THEREFROM
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP1973960A2

  公开（公告）日：2008-10-01
• AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP2069332B1

  公开（公告）日：2011-03-02
• Polyester oligomers, methods of making, and thermosetting compositions formed therefrom
  申请人：Berti Corrado

  公开号：US20070155946A1

  公开（公告）日：2007-07-05

  The above deficiencies in the art are alleviated by, in an embodiment, a method of preparing a carboxylic acid end-capped oligomer comprising melt reacting a dicarboxylic acid, a dihydroxy compound, a hydroxy end-capped soft block compound, a diaryl carbonate, and a catalyst, wherein the molar ratio of dihydroxy end-capped soft block compound to dihydroxy compound is 1:4 to 1:40, the molar ratio of dicarboxylic acid to the combined molar amounts of dihydroxy compound and hydroxy end-capped soft block compound is 1.01:1 to 2:1, and the molar ratio of diaryl carbonate to the combined molar amounts of dihydroxy compound and hydroxy end-capped soft block compound is 1.5:1 to 3:1. A carboxylic acid end-capped oligomer prepared by the above method is also disclosed. A thermosetting composition comprising the carboxylic acid end-capped oligomer, and an article comprising the thermosetting composition, are also disclosed.
• US7994336B2
  申请人：——

  公开号：US7994336B2

  公开（公告）日：2011-08-09
• [EN] POLYESTER OLIGOMERS, METHODS OF MAKING, AND THERMOSETTING COMPOSITIONS FORMED THEREFROM<br/>[FR] OLIGOMERES DE POLYESTER, PROCEDES DE FABRICATION, ET COMPOSITIONS THERMODURCISSABLES A BASE DE CES OLIGOMERES DE POLYESTER
  申请人：GEN ELECTRIC

  公开号：WO2007081539A2

  公开（公告）日：2007-07-19

  [EN] The above deficiencies, in the art are alleviated by, in an embodiment, a method of preparing a carboxylic acid end-capped oligomer comprising melt reacting a dicarboxylic acid, a dihydroxy compound, a hydroxy end-capped soft block compound, a diaryl carbonate, and a catalyst, wherein the molar ratio of dihydroxy end-capped soft block compound to dihydroxy compound is 1:4 to 1:40, the molar ratio of dicarboxylic acid to the combined molar amounts of dihydroxy compound and hydroxy end-capped soft block compound is 1.01:1 to 2:1, and the molar ratio of diaryl carbonate to the combined molar amounts of dihydroxy compound and hydroxy end-capped soft block compound is 1.5:1 to 3:1. A carboxylic acid end-capped oligomer prepared by the above method is also disclosed. A thermosetting composition comprising the carboxylic acid end-capped oligomer, and an article comprising the thermosetting composition, are also disclosed.
  [FR] Selon l'invention, les lacunes précitées de la technique sont résolues, dans un mode de réalisation, par un procédé de préparation d'un oligomère à coiffe d'extrémité acide carboxylique consistant à faire réagir par fusion un acide dicarboxylique, un composé dihydroxy, un composé de bloc mou à coiffe d'extrémité hydroxy, un carbonate de dyaryle, et un catalyseur. Le rapport molaire du composé de bloc mou à coiffe d'extrémité dihydroxy sur le composé dihydroxy est compris entre 1:4 et 1:40, le rapport molaire de l'acide dicarboxylique sur les quantités molaires combinées du composé dihydroxy et du composé de bloc mou à coiffe d'extrémité hydroxy est compris entre 1,01:1 à 2:1, et le rapport molaire du carbonate de diaryle sur les quantités molaires combinées du composé dihydroxy et du composé de bloc mou à coiffe d'extrémité hydroxy est compris entre 1,5:1 et 3:1. L'invention concerne également un oligomère à coiffe d'extrémité acide carboxylique préparé selon le procédé précité. Elle concerne enfin une composition thermodurcissable comprenant l'oligomère à coiffe d'extrémité acide carboxylique, et un article comprenant cette composition thermodurcissable.