N-Benzyl-4-[(N-2-phenylethyl-N-(4-chlorophenyl)sulphonyl)amino]-piperidine | 370886-13-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-Benzyl-4-[(N-2-phenylethyl-N-(4-chlorophenyl)sulphonyl)amino]-piperidine
• 英文别名: N-(1-benzylpiperidin-4-yl)-4-chloro-N-(2-phenylethyl)benzenesulfonamide
• CAS: 370886-13-8
• 化学式: C₂₆H₂₉ClN₂O₂S
• 分子量: 469.047
• InChiKey: XRXSUWCNKRHHCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  49
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Aminopiperidines
  申请人：——

  公开号：US20030176461A1

  公开（公告）日：2003-09-18

  Described herein are compounds having general formula (1), wherein groups R 1 , R 2 , R 3 , Ar 1 , Ar 2 , Ar 3 , X, Y, p and n are as defined in the specification, and a salt, solvate and hydrate thereof. Such compounds inhibit glycine transport (or reuptake) via the GlyT-1 transporter, or are precursors (for example, pro-drugs) of such compounds and, thus, are useful in the treatment of schizophrenia, as well as other CNS-related disorders such as dementia, Alzheimer's disease, attention deficit disorder and depression.

  本文描述的化合物具有一般式（1），其中基团R1、R2、R3、Ar1、Ar2、Ar3、X、Y、p和n如规范中所定义，并且其盐、溶剂合物和水合物。这些化合物通过GlyT-1转运蛋白抑制甘氨酸的转运（或重新摄取），或者是这些化合物的前体（例如，前药），因此在治疗精神分裂症以及其他中枢神经系统相关疾病，如痴呆症、阿尔茨海默病、注意力缺陷障碍和抑郁症方面是有用的。
• AMINOPIPERIDINES FOR USE AS GLYT-1 INHIBITORS
  申请人：NPS Allelix Corp.

  公开号：EP1296950A2

  公开（公告）日：2003-04-02
• [EN] AMINOPIPERIDINES<br/>[FR] AMINOPIPERIDINES
  申请人：NPS ALLELIX CORP

  公开号：WO2001081308A2

  公开（公告）日：2001-11-01

  Described herein are compounds having general formula (I), wherein groups R1, R2, R3, Ar1, Ar2, Ar3, X, Y, p and n are as defined in the specification, and a salt, solvate and hydrate thereof. Such compounds inhibit glycine transport (or reuptake) via the GlyT-1 transporter, or are precursors (for example, pro-drugs) of such compounds and, thus, are useful in the treatment of schizophrenia, as well as other CNS-related disorders such as dementia, Alzheimer's disease, attention deficit disorder and depression.