3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-2,4,6-trifluorophenylamine | 882745-67-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-2,4,6-trifluorophenylamine
• 英文别名: 3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]piperidin-4-yl]-2,4,6-trifluoroaniline
• CAS: 882745-67-7
• 化学式: C₂₄H₂₁F₅N₂O
• 分子量: 448.436
• InChiKey: BWEGUQWMIMNEEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38.5
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Amino substituted aryloxybenzylpiperidine derivatives
  申请人：Marzabadi R. Mohammad

  公开号：US20060079524A1

  公开（公告）日：2006-04-13

  This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.

  本发明涉及氨基酸取代的芳氧基苄基哌啶衍生物，这些衍生物是MCH1受体的配体。本发明提供了一种药用组合物，其包含本发明的化合物以及药学上可接受的载体的治疗有效量。本发明还提供了一种通过混合本发明的化合物的治疗有效量和药学上可接受的载体制备的药用组合物。本发明进一步提供了一种制备药用组合物的方法，该方法包括将本发明的化合物的治疗有效量与药学上可接受的载体结合。本发明还提供了一种治疗患有抑郁和/或焦虑的受试者的方法，该方法包括向受试者施用本发明的化合物的治疗有效量。本发明还提供了一种治疗患有肥胖的受试者的方法，该方法包括向受试者施用本发明的化合物的治疗有效量。
• AMINO SUBSTITUTED ARYLOXYBENZYLPIPERIDINE DERIVATIVES
  申请人：H.Lundbeck A/S

  公开号：EP1804796A2

  公开（公告）日：2007-07-11
• US7446204B2
  申请人：——

  公开号：US7446204B2

  公开（公告）日：2008-11-04
• [EN] AMINO SUBSTITUTED ARYLOXYBENZYLPIPERIDINE DERIVATIVES<br/>[FR] DERIVES D'ARYLOXYBENZYLPIPERIDINE AMINO-SUBSTITUES
  申请人：LUNDBECK & CO AS H

  公开号：WO2006041636A2

  公开（公告）日：2006-04-20

  This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/ or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.