tert-butyl 3-{3-[2-(benzyloxy)-6-hydroxyphenyl]-3-oxopropanoyl}piperidine-1-carboxylate | 868284-02-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl 3-{3-[2-(benzyloxy)-6-hydroxyphenyl]-3-oxopropanoyl}piperidine-1-carboxylate
• 英文别名: Tert-butyl 3-[3-(2-hydroxy-6-phenylmethoxyphenyl)-3-oxopropanoyl]piperidine-1-carboxylate
• CAS: 868284-02-0
• 化学式: C₂₆H₃₁NO₆
• 分子量: 453.535
• InChiKey: GHXFOLSBPAAUAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  93.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 2-Aminopyrimidine Derivative
  申请人：Okamoto Yoshinori

  公开号：US20070265289A1

  公开（公告）日：2007-11-15

  The invention relates to a compound useful as remedies or preventives for IKK2-related inflammatory diseases or autoimmune diseases, or that is, a 2-aminopyrimidine derivative having a 2-hydroxyphenyl group at the 6-position thereof and having a saturated cyclic group that contains one nitrogen atom, such as piperidine, at the 4-position thereof. The pharmaceutical composition of the invention and the compound of the invention have an excellent antiinflammatory effect based on the IKK2-inhibitory effect thereof, and are therefore useful for remedies and preventives for inflammatory diseases and autoimmune diseases, especially for rheumatoid arthritis.

  本发明涉及一种化合物，可用作治疗或预防IKK2相关的炎症性疾病或自身免疫性疾病的药物，即在其6位具有2-羟基苯基基团并且在其4位具有含有一个氮原子的饱和环状基团（例如哌啶）的2-氨基嘧啶衍生物。本发明的制药组合物和该化合物具有出色的抗炎作用，基于其IKK2抑制作用，因此对于治疗和预防炎症性疾病和自身免疫性疾病特别是类风湿性关节炎非常有用。
• 2-AMINOPYRIDINE DERIVATIVE
  申请人：Astellas Pharma Inc.

  公开号：EP1736472A1

  公开（公告）日：2006-12-27

  The invention relates to a compound useful as remedies or preventives for IKK2-related inflammatory diseases or autoimmune diseases, or that is, a 2-aminopyrimidine derivative having a 2-hydroxyphenyl group at the 6-position thereof and having a saturated cyclic group that contains one nitrogen atom, such as piperidine, at the 4-position thereof. The pharmaceutical composition of the invention and the compound of the invention have an excellent antiinflammatory effect based on the IKK2-inhibitory effect thereof, and are therefore useful for remedies and preventives for inflammatory diseases and autoimmune diseases, especially for rheumatoid arthritis.

  本发明涉及一种可用于治疗或预防与IKK2相关的炎症性疾病或自身免疫性疾病的化合物，或者说是一种2-氨基嘧啶衍生物，其6位上具有2-羟基苯基，4位上具有含有一个氮原子的饱和环状基团，如哌啶。本发明的药物组合物和本发明的化合物基于其对 IKK2 的抑制作用，具有极佳的抗炎效果，因此可用于炎症性疾病和自身免疫性疾病，尤其是类风湿性关节炎的治疗和预防。