biphenyl-2-ylcarbamic acid 1-[2-fluoro-3-(4-{3-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}piperidin-1-ylmethyl)benzyl]piperidin-4-yl ester | 743462-22-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: biphenyl-2-ylcarbamic acid 1-[2-fluoro-3-(4-{3-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]propyl}piperidin-1-ylmethyl)benzyl]piperidin-4-yl ester
• 英文别名: [1-[[2-fluoro-3-[[4-[3-[[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]propyl]piperidin-1-yl]methyl]phenyl]methyl]piperidin-4-yl] N-(2-phenylphenyl)carbamate
• CAS: 743462-22-8
• 化学式: C₄₅H₅₂FN₅O₅
• 分子量: 761.937
• InChiKey: YXEMCZDGFMKPBJ-RWYGWLOXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  56
• 可旋转键数：
  15
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  126
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Biphenyl derivatives
  申请人：——

  公开号：US20040167167A1

  公开（公告）日：2004-08-26

  This invention provides biphenyl derivatives of formula I: 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both &bgr; 2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

  这项发明提供了式I中的联苯衍生物：其中R1、R2、R3、R4、R5、R6、R7、W、a、b和c如规范中定义，或其药学上可接受的盐、溶剂或立体异构体。本发明的联苯衍生物具有β2肾上腺素受体激动剂和肌力抑制剂活性，因此，这种联苯衍生物可用于治疗肺部疾病，如慢性阻塞性肺疾病和哮喘。
• BIPHENYL DERIVATIVE AND ITS USE FOR TREATING PULMONARY DISORDERS
  申请人：Theravance Respiratory Company, LLC

  公开号：EP3012254A1

  公开（公告）日：2016-04-27

  This invention relates to a biphenyl derivative useful for treating pulmonary disorders such as chronic obstructive pulmonary disease and asthma. The invention also relates to pharmaceutical compositions comprising such a biphenyl derivative and such a biphenyl derivative for use in therapy.

  本发明涉及一种可用于治疗慢性阻塞性肺病和哮喘等肺部疾病的联苯衍生物。本发明还涉及包含这种联苯衍生物的药物组合物和用于治疗的这种联苯衍生物。
• EP1615889A2
  申请人：——

  公开号：EP1615889A2

  公开（公告）日：2006-01-18
• BIPHENYL DERIVATIVES HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
  申请人：Theravance Respiratory Company, LLC

  公开号：EP2246345B1

  公开（公告）日：2016-02-10
• US7141671B2
  申请人：——

  公开号：US7141671B2

  公开（公告）日：2006-11-28