5'-O-dimethoxytrityl-6-N-(5-azapentane-1-yl)-2'-deoxyadenosine | 244639-80-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5'-O-dimethoxytrityl-6-N-(5-azapentane-1-yl)-2'-deoxyadenosine
• 英文别名: (2R,3S,5R)-5-[6-(4-aminobutylamino)purin-9-yl]-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-ol
• CAS: 244639-80-3
• 化学式: C₃₅H₄₀N₆O₅
• 分子量: 624.74
• InChiKey: REJLQPWKNBJRBR-OJDZSJEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  46
• 可旋转键数：
  14
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  139
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  三氟乙酸酐 、 5'-O-dimethoxytrityl-6-N-(5-azapentane-1-yl)-2'-deoxyadenosine 在 吡啶 作用下， 生成 5'-O-dimethoxytrityl-6-N-[(N-trifluoroacetyl)-5-azapentane-1-yl]-2'-deoxyadenosine
  参考文献：
  名称：

  Synthesis of Polyaminooligonucleotides and Their Combinatorial Libraries

  摘要：

  A synthesis of phosphoramidites of 2'-deqxyadenosine and 2'-deoxyguanosine carrying a protected spermine moiety at N-6 and N-2 positions respectively is described. An approach to analyse properties of polyaminooligonucleotides using their synthetic combinatorial libraries is described and discussed. A synthesis of a polyaminooligonucleotide combinatorial library was carried out and the analysis of the library clearly showed that the presence of spermine moieties in oligodeoxyribonucleotides increases stability of their complexes.

  DOI：

  10.1080/07328319908044749
• 作为产物：
  描述：

  9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-(1,2,4-triazol-4-yl)purine 以 吡啶 为溶剂， 生成 5'-O-dimethoxytrityl-6-N-(5-azapentane-1-yl)-2'-deoxyadenosine
  参考文献：
  名称：

  Synthesis of Polyaminooligonucleotides and Their Combinatorial Libraries

  摘要：

  A synthesis of phosphoramidites of 2'-deqxyadenosine and 2'-deoxyguanosine carrying a protected spermine moiety at N-6 and N-2 positions respectively is described. An approach to analyse properties of polyaminooligonucleotides using their synthetic combinatorial libraries is described and discussed. A synthesis of a polyaminooligonucleotide combinatorial library was carried out and the analysis of the library clearly showed that the presence of spermine moieties in oligodeoxyribonucleotides increases stability of their complexes.

  DOI：

  10.1080/07328319908044749