ethyl 4-(4-{5-[3-ethyl-4-(1-piperidinyl)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indazol-1-yl)butanoate | 1072948-19-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: ethyl 4-(4-{5-[3-ethyl-4-(1-piperidinyl)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indazol-1-yl)butanoate
• 英文别名: Ethyl 4-[4-[5-(3-ethyl-4-piperidin-1-ylphenyl)-1,2,4-oxadiazol-3-yl]indazol-1-yl]butanoate
• CAS: 1072948-19-6
• 化学式: C₂₈H₃₃N₅O₃
• 分子量: 487.602
• InChiKey: XOBFHUXYTRMYRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  86.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds
  申请人：Sattigeri Viswajanani Jitendra

  公开号：US20090075909A1

  公开（公告）日：2009-03-19

  The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds of this invention can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases, for example, bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. The present invention also relates to pharmacological compositions containing these monosaccharide derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or auto immune disorders.

  本发明涉及单糖衍生物作为抗炎药剂。本发明的化合物可用于抑制和预防炎症及相关病理，包括炎症性和自身免疫性疾病，例如支气管哮喘、类风湿关节炎、I 型糖尿病、多发性硬化症、移植排斥或牛皮癣。本发明还涉及含有这些单糖衍生物的药物组合物，以及治疗支气管哮喘、慢性阻塞性肺病、类风湿关节炎、多发性硬化症、I 型糖尿病、牛皮癣、移植排斥和其他炎症和/或自身免疫性疾病的方法。
• OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS
  申请人：Ahmed Mahmood

  公开号：US20100113528A1

  公开（公告）日：2010-05-06

  The present invention provides compounds of formula (I) or salts thereof: having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders mediated by S1P1 receptors.

  本发明提供式（I）的化合物或其盐：具有药理活性，它们的制备过程，包含它们的制药组合物以及它们在治疗由S1P1受体介导的各种疾病中的应用。
• US8324254B2
  申请人：——

  公开号：US8324254B2

  公开（公告）日：2012-12-04
• [EN] OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS<br/>[FR] DÉRIVÉS D'INDAZOLE SUBSTITUÉS PAR OXADIAZOLE, DESTINÉS À ÊTRE UTILISÉS COMME AGONISTES DE LA SPHINGOSINE 1-PHOSPHATE (S1P)
  申请人：GLAXO GROUP LTD

  公开号：WO2008128951A1

  公开（公告）日：2008-10-30

  [EN] The present invention provides compounds of formula (I) or salts thereof, having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders mediated by S1P1 receptors.
  [FR] La présente invention porte sur des composés de formule (I) ou des sels de ceux-ci, ayant une activité pharmacologique, sur des procédés pour leur préparation, sur des compositions pharmaceutiques les contenant, et sur leur utilisation dans le traitement de divers troubles liés aux récepteurs de S1P1.