4-Phenyl-3,15-dioxatetracyclo[6.6.1.02,6.09,14]pentadeca-2(6),4,9,11,13-pentaene | 1411840-80-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环七呋喃
• 英文名称: 4-Phenyl-3,15-dioxatetracyclo[6.6.1.02,6.09,14]pentadeca-2(6),4,9,11,13-pentaene
• 英文别名: 4-phenyl-3,15-dioxatetracyclo[6.6.1.02,6.09,14]pentadeca-2(6),4,9,11,13-pentaene
• CAS: 1411840-80-6
• 化学式: C₁₉H₁₄O₂
• 分子量: 274.319
• InChiKey: QVOLUZXUHMAGFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  22.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-苯基-2-丙炔-1-酮 在 trans-di(1-acetato)bis[5-(diphenyl-phosphino)naphth-1-yl]dipalladium(II) 、 大茴香酸 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 4-Phenyl-3,15-dioxatetracyclo[6.6.1.02,6.09,14]pentadeca-2(6),4,9,11,13-pentaene
  参考文献：
  名称：

  Palladacycle-Catalyzed Reaction of Bicyclic Alkenes with Terminal Ynones: Regiospecific Synthesis of Polysubstituted Furans

  摘要：

  A new synthetic strategy to access polysubstituted furans regiospecifically has been developed using simple bicyclic alkenes and terminal ynones as starting materials with palladacycles as unique active catalysts. A rational mechanism has also been proposed. This reaction features mild reaction conditions, easily available starting materials and palladacycle catalysts, a wide substrate scope, and high regiospecificity.

  DOI：

  10.1021/ol302586m

文献信息

• Palladacycle-Catalyzed Reaction of Bicyclic Alkenes with Terminal Ynones: Regiospecific Synthesis of Polysubstituted Furans
  作者：Guang-Cun Ge、Dong-Liang Mo、Chang-Hua Ding、Li-Xin Dai、Xue-Long Hou

  DOI：10.1021/ol302586m

  日期：2012.11.16

  A new synthetic strategy to access polysubstituted furans regiospecifically has been developed using simple bicyclic alkenes and terminal ynones as starting materials with palladacycles as unique active catalysts. A rational mechanism has also been proposed. This reaction features mild reaction conditions, easily available starting materials and palladacycle catalysts, a wide substrate scope, and high regiospecificity.