(3R,4S)-N-cyclopropyl-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-N-[3-(2-dimethylamino-ethoxy)-5-(3-methoxypropyl)benzyl]piperidine-3-carboxamide | 1026787-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3R,4S)-N-cyclopropyl-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-N-[3-(2-dimethylamino-ethoxy)-5-(3-methoxypropyl)benzyl]piperidine-3-carboxamide
• 英文别名: (3R,4S)-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-N-(3-(2-(dimethylamino)ethoxy)-5-(3-methoxypropyl)benzyl)piperidine-3-carboxamide；(3R,4S)-N-cyclopropyl-4-[4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl]-N-[[3-[2-(dimethylamino)ethoxy]-5-(3-methoxypropyl)phenyl]methyl]piperidine-3-carboxamide
• CAS: 1026787-19-8
• 化学式: C₃₉H₅₁Cl₂N₃O₅
• 分子量: 712.757
• InChiKey: GLYFGYIXZOBFGF-GPOMZPHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  49
• 可旋转键数：
  18
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• RENIN INHIBITORS
  申请人：Dube Daniel

  公开号：US20100063091A1

  公开（公告）日：2010-03-11

  The present invention relates to disubstituted piperidinyl renin inhibitor compounds having the structure (Formula I) and their use in treating cardiovascular events and renal insufficiency.

  本发明涉及具有结构式（式I）的二取代哌啶基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的应用。
• Biochemical markers for CVD risk assessment
  申请人：Nordic Bioscience Imaging A/S

  公开号：EP2538218A2

  公开（公告）日：2012-12-26

  A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque, wherein the protein is biglycan and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

  一种生物检测方法，用于量化包含由动脉粥样硬化斑块的蛋白质裂解形成的新表位的肽片段，其中该蛋白质为biglycan，所述方法包括将尿液或血清等样本与与新表位反应的抗体接触，并确定所述免疫结合伴侣与所述样本中的肽片段的结合水平。该检测方法可预测心血管疾病事件的风险。
• NATURAL KILLER CELL-SPECIFIC ANTIGEN AND ANTIBODIES THAT IDENTIFY THE SAME
  申请人：DANA FARBER CANCER INSTITUTE

  公开号：EP0714510A1

  公开（公告）日：1996-06-05
• EP0714510A4
  申请人：——

  公开号：EP0714510A4

  公开（公告）日：1999-06-09
• BIOCHEMICAL MARKERS FOR CVD RISK ASSESSMENT
  申请人：Nordic Bioscience A/S

  公开号：EP2208073A2

  公开（公告）日：2010-07-21