硅烷胺,1,1,1-三乙基-N-[1-[(三乙基甲硅烷基)氧代]亚乙基]- | 106073-57-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: 硅烷胺,1,1,1-三乙基-N-[1-[(三乙基甲硅烷基)氧代]亚乙基]-
• 英文名称: N,O-bis(triethylsilyl)acetamide
• CAS: 106073-57-8
• 化学式: C₁₄H₃₃NOSi₂
• 分子量: 287.593
• InChiKey: WKPFPVINAYQJQJ-UHFFFAOYSA-N

物化性质

• 沸点：
  298.2±23.0 °C(Predicted)
• 密度：
  0.84±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.43
• 重原子数：
  18.0
• 可旋转键数：
  8.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  21.59
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  乙酰胺 、 三乙基硅烷 在 Pd/G 作用下， 以 neat (no solvent) 为溶剂， 反应 0.5h， 生成 硅烷胺,1,1,1-三乙基-N-[1-[(三乙基甲硅烷基)氧代]亚乙基]-
  参考文献：
  名称：

  负载在石墨烯上的钯纳米颗粒作为氢化硅烷与胺类脱氢偶联的催化剂†

  摘要：

  钯纳米粒子（Pd NPs）负载在未掺杂和N或B掺杂的石墨烯（Gs）上，这些材料已用作催化剂，用于氢化硅烷和胺的脱氢偶联反应，形成硅氮烷。在最佳条件下工作，对于二甲基苯基硅烷与吗啉的反应，可实现超过99％的转化率和84％的选择性。相反，负载在G上的铜（Cu NPs）或镍纳米颗粒（Ni NPs）不会促进相应的Si-N偶联产物的形成。已发现，Pd / G的偶联性能优于类似的催化剂，其中Pd NPs负载在活性炭，多壁碳纳米管或金刚石NPs上。作为催化剂的Pd / G具有广泛的底物范围，包括脂肪族和芳香族胺以及单或二氢硅烷。

  DOI：

  10.1039/c4cy01486c
• 作为试剂：
  描述：

  胸腺嘧啶 、 Benzoic acid (R)-4,4-difluoro-5-methanesulfonyloxy-tetrahydro-furan-2-ylmethyl ester 在 硅烷胺,1,1,1-三乙基-N-[1-[(三乙基甲硅烷基)氧代]亚乙基]- 、 sodium iodide 作用下， 生成 Benzoic acid (2R,5S)-4,4-difluoro-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 、 Benzoic acid (2R,5R)-4,4-difluoro-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
  参考文献：
  名称：

  Synthesis of 2,3-dideoxy-2,2-difluoro-l-glycero-pentofuranosyl nucleosides

  摘要：

  Various 2,3-dideoxy-2,2-difluoro-L-glycero-pentofuranosyl nucleosides were synthesized via the key intermediate, 5-O-benzoyl-2,3-dideoxy-2,2-difluoro-L-glycero-pentofuranose (6). 2,3-O-Isopropylidene-L-glyceraldehyde was coupled with ethyl bromodifluoroacetate under Reformatsky conditions to obtain the diastereomeric mixture of ethyl (4S)-3-hydroxy-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro propionate (1). Treatment of compound 1 with carbon disulfide, sodium hydride and methyl iodide followed by reduction afforded ethyl (4S)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro propionate (3). Compound 3 was treated with 5% HCl in ethanol, followed by refluxing in benzene under Dean-Stark conditions, to afford the lactone 4. The compound 4 was protected and reduced to afford the key intermediate 6. For the synthesis of pyrimidine derivatives 8-21, compound 6 was converted to the mesylate 7 and condensed with various silyl protected pyrimidine bases. The inosine and adenine derivatives 38-41 were obtained from compound 6 and 6-chloropurine using standard procedures. Compounds 22-35 and 38-41 were evaluated for their antiviral activity against HIV-1, HBV, HSV-1 and HSV-2, and for cellular toxicity. None of the synthesized compounds showed any significant activity or toxicity. Single-crystal X-ray structure of 1-(2,3-dideoxy-2,2-difluoro-beta-L-glycero-pentofuranosyl)-5-iodocytosine (34) suggested a 2'-exo/3'-endo conformation for the carbohydrate moiety. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(97)00275-9