3,3-Dimethylpiperidine-2,5-dione | 2059987-11-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3,3-Dimethylpiperidine-2,5-dione
• CAS: 2059987-11-8
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: UWHREJZRZKMNDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] N-[4-OXO-2,3-DIHYDRO-1,5-BENZOXAZEPIN-3-YL]-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL E-2-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS RIP1 KINASE INHIBITORS FOR TREATING E.G. IRRITABLE BOWEL SYNDROME (IBS)<br/>[FR] DÉRIVÉS DE N-[4-OXO-2,3-DIHYDRO-1,5-BENZOXAZÉPIN-3-YL]-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL E-2-CARBOXAMIDE ET COMPOSÉS APPARENTÉS EN TANT QU'INHIBITEURS DE LA KINASE RIP1 POUR LE TRAITEMENT, PAR EXEMPLE, DU SYNDROME DU CÔLON IRRITABLE (IBS)
  申请人：GENENTECH INC

  公开号：WO2019204537A1

  公开（公告）日：2019-10-24

  The invention provides compounds having the general formula (I): or pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, R7a, R7b, X, RB1, RB2, n, p, q, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and the compounds for use as receptor-interacting protein-1 (RIP1) kinase inhibitors in methods of treating e.g. Parkinson's or Alzheimer's disease, irritable bowel disorders (IBD), Crohn's disease, respiratory distress syndrome (ARDS) or chronic obstructive pulmonary disease (COPD). An exemplary compound is e.g. (4S,6S)-4-fluoro-6-phenyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-l,5- benzoxazepin-3-yl]-5,6-dihydro-4H-pyrrolo[l,2-b]pyrazole-2- carboxamide (example 11) with a Ki (uM) in a RIP1 assay of 0.0044 uM..