1-[3-(1-allylpiperidin-4-yl)-2-fluorophenyl]-2,2,2-trifluoroethanone | 871352-72-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[3-(1-allylpiperidin-4-yl)-2-fluorophenyl]-2,2,2-trifluoroethanone
• 英文别名: 2,2,2-trifluoro-1-[2-fluoro-3-(1-prop-2-enylpiperidin-4-yl)phenyl]ethanone
• CAS: 871352-72-6
• 化学式: C₁₆H₁₇F₄NO
• 分子量: 315.311
• InChiKey: GHBBSVYCHSGMKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,2,2-trifluoro-1-(2-fluoro-3-piperidin-4-ylphenyl)ethanone 、 potassium carbonate 、 3-溴丙烯 、 、 、 以 乙腈 为溶剂， 生成 1-[3-(1-allylpiperidin-4-yl)-2-fluorophenyl]-2,2,2-trifluoroethanone
  参考文献：
  名称：

  DISUBSTITUTED PHENYLPIPERDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION

  摘要：

  本发明涉及具有治疗中枢神经系统疾病作用的化合物，具体而言是新的4-(邻、间二取代苯基)-1-烷基哌啶和哌嗪，其中R1、R2、R3和X的定义如下。

  公开号：

  US20100256163A1

文献信息

• [EN] NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION<br/>[FR] NOUVELLES PHENYLPIPERIDINES/PIPERAZINES DISUBSTITUES UTILISEES COMME MODULATEURS DE NEUROTRANSMISSION DE LA DOPAMINE
  申请人：CARLSSON A RESEARCH AB

  公开号：WO2005121087A1

  公开（公告）日：2005-12-22

  The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho, meta-disubstituted phenyl)-1-alkypiperidines and piperazines. (I) wherein R1, R2, R3 and Y are as defined.

  本发明涉及具有治疗中枢神经系统紊乱作用的化合物，特别是新的4-(邻、间二取代苯基)-1-烷基哌啶和哌嗪。其中R1、R2、R3和Y的定义如下。
• [EN] TOPICAL SLIMMING PREPARATION AND A COSMETIC CONTAINING A CARNITINE DERIVATIVE<br/>[FR] PRÉPARATION EXTERNE POUR L'AMINCISSEMENT DE LA PEAU ET PRODUIT COSMÉTIQUE CONTENANT CETTE PRÉPARATION
  申请人：SHOWA DENKO KK

  公开号：WO2005115326A1

  公开（公告）日：2005-12-08

  The invention provides a slimming skin external preparation and a cosmetic that contain a carnitine derivative having excellent skin affinity and percutaneous absorption properties and capable of enhancing the fat metabolism, and that can treat, reduce or prevent the obesity by functioning as a lipolytic agent to enhance the fat metabolism of general or local subcutaneous fat tissues. The slimming skin external preparation contains a particular carnitine derivative such as a cylcarnitines and alcohol carnitine esters and preferably other slimming and skin-care ingredients.

  本发明提供了一种减肥皮肤外用制剂和化妆品，其中包含一种肉碱衍生物，具有优异的皮肤亲和性和经皮吸收性能，能够增强脂肪代谢，并且能够作为脂肪分解剂，促进一般或局部皮下脂肪组织的脂肪代谢，从而治疗、减少或预防肥胖。该减肥皮肤外用制剂包含特定的肉碱衍生物，如环肉碱和醇肉碱酯，并且最好还包含其他减肥和护肤成分。
• Slimming Skin External Preparation and Cosmetic Containing the Same
  申请人：Shibuya Akira

  公开号：US20070232698A1

  公开（公告）日：2007-10-04

  The invention provides a slimming skin external preparation and a cosmetic that contain a carnitine derivative having excellent skin affinity and percutaneous absorption properties and capable of enhancing the fat metabolism, and that can treat, reduce or prevent the obesity by functioning as a lipolytic agent to enhance the fat metabolism of general or local subcutaneous fat tissues. The slimming skin external preparation contains a particular carnitine derivative and preferably other slimming and skin-care ingredients.

  该发明提供了一种含有卡尼汀衍生物的减肥皮肤外用制剂和化妆品，该衍生物具有优异的皮肤亲和性和经皮吸收性能，并能够增强脂肪代谢，通过作为脂肪分解剂增强一般或局部皮下脂肪组织的脂肪代谢，从而能够治疗、减少或预防肥胖。该减肥皮肤外用制剂含有特定的卡尼汀衍生物，最好还包含其他减肥和护肤成分。
• DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION
  申请人：Sonesson Clas

  公开号：US20070149542A1

  公开（公告）日：2007-06-28

  The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho,meta-disubstituted phenyl)-1-alkypiperidines and piperazines. wherein R1, R2, R3 and X are as defined.

  本发明涉及对中枢神经系统疾病具有治疗效果的化合物，特别是新的4-(邻、间二取代苯基)-1-烷基哌啶和哌嗪，其中R1，R2，R3和X如定义。
• Disubstituted phenylpiperidines/piperazines as modulators of dopamine neurotransmission
  申请人：NSAB, Filial AF Neurosearch Sweden AB, Sverige

  公开号：US07763639B2

  公开（公告）日：2010-07-27

  The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho, meta-disubstituted phenyl)-1-alkypiperidines and piperazines. wherein R1, R2, R3 and X are as defined.

  本发明涉及对中枢神经系统疾病具有治疗效果的化合物，特别是新的4-(邻、间二取代苯基)-1-烷基哌啶和哌嗪，其中R1、R2、R3和X的定义如下。