8-[1-[(2-Aminopyridin-4-yl)methyl]piperidine-4-carbonyl]-2-[4-(trifluoromethyl)phenyl]-2,8-diazaspiro[4.5]decan-1-one | 1215120-63-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 8-[1-[(2-Aminopyridin-4-yl)methyl]piperidine-4-carbonyl]-2-[4-(trifluoromethyl)phenyl]-2,8-diazaspiro[4.5]decan-1-one
• CAS: 1215120-63-0
• 化学式: C₂₇H₃₂F₃N₅O₂
• 分子量: 515.579
• InChiKey: ORJQZGCSGVDMKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  82.8
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE
  申请人：McCormick Kevin D.

  公开号：US20110166124A1

  公开（公告）日：2011-07-07

  The present invention relates to novel Tricyclic Spirocycle Derivatives, pharmaceutical compositions comprising the Tricyclic Spirocycle Derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or aired fasting glucose.

  本发明涉及新型三环螺环衍生物，包括该三环螺环衍生物的药物组合物，以及利用这些化合物治疗或预防过敏、过敏引起的气道反应、充血、心血管疾病、炎症性疾病、消化系统紊乱、神经系统紊乱、代谢紊乱、肥胖或与肥胖相关的疾病、糖尿病、糖尿病并发症、糖耐量受损或空腹血糖异常。
• [EN] TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE THEREOF<br/>[FR] DÉRIVÉS SPIROCYCLIQUES TRICYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SCHERING CORP

  公开号：WO2010027567A2

  公开（公告）日：2010-03-11

  The present invention relates to novel Tricyclic Spirocycle Derivatives, pharmaceutical compositions comprising the Tricyclic Spirocycle Derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disoder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.