[2-(2,5-dichlorophenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinolin)-6-yl](4-methanesulfonylpiperazin-1-yl)methanone | 1353969-65-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [2-(2,5-dichlorophenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinolin)-6-yl](4-methanesulfonylpiperazin-1-yl)methanone
• 英文别名: [2-(2,5-dichloro-phenyl)-spiro(cyclopropane-1,4'-1',2''3',4'-tetrahydroquinolin)-6-yl]-(4-methanesulfonyl-piperazin-l-yl)-methanone；[2-(2,5-dichlorophenyl)spiro[2,3-dihydro-1H-quinoline-4,1'-cyclopropane]-6-yl]-(4-methylsulfonylpiperazin-1-yl)methanone
• CAS: 1353969-65-9
• 化学式: C₂₃H₂₅Cl₂N₃O₃S
• 分子量: 494.442
• InChiKey: FLUCVUDGXNCIOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  78.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• NOVEL TETRAHYDRO-QUINOLINE DERIVATIVES
  申请人：Chen Li

  公开号：US20120004218A1

  公开（公告）日：2012-01-05

  A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A 1 to A 3 and R 1 to R 10 have the significance given in claim 1 , can be used as a medicament. These compounds are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.

  式（I）的化合物或其药用可接受的盐或酯，其中A1至A3和R1至R10具有权利要求1中给定的含义，可用作药物。这些化合物在与AMPK调节相关的疾病的治疗或预防中非常有用，如肥胖、血脂异常、高血糖、1型或2型糖尿病和癌症。