(R)-1-acryloylpiperidine-3-carboxylic acid | 1568017-07-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (R)-1-acryloylpiperidine-3-carboxylic acid
• 英文别名: (3R)-1-(prop-2-enoyl)piperidine-3-carboxylic acid；(3R)-1-prop-2-enoylpiperidine-3-carboxylic acid
• CAS: 1568017-07-1
• 化学式: C₉H₁₃NO₃
• 分子量: 183.207
• InChiKey: VBROFLVSVXVQEG-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] HETEROCYCLYL SUBSTITUTED PYRROLOPYRIDINES THAT ARE INHIBITORS OF THE CDK12 KINASE<br/>[FR] PYRROLOPYRIDINES À SUBSTITUTION HÉTÉROCYCLYLE UTILISÉES EN TANT QU'INHIBITEURS DE LA KINASE CDK12
  申请人：UNIV NOTTINGHAM

  公开号：WO2019058132A1

  公开（公告）日：2019-03-28

  This invention relates to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular,the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R1a, R2, R3, R4a, R4b and R4c are as defined herein.

  这项发明涉及抑制CDK12激酶的化合物。这些化合物可用于治疗由CDK12激酶介导的疾病，包括1型肌强直性营养不良（DM1）和其他由RNA重复扩展转录物引起的疾病。特别是，该发明涉及公式（I）的化合物，或其药用可接受的盐或N-氧化物，其中R1a, R2, R3, R4a, R4b和R4c按本文定义。
• HETEROCYCLYL SUBSTITUTED PYRROLOPYRIDINES THAT ARE INHIBITORS OF THE CDK12 KINASE
  申请人：The University of Nottingham

  公开号：EP3684776A1

  公开（公告）日：2020-07-29
• STABILIZED PEPTIDES FOR COVALENT BINDING TO TARGET PROTEIN
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20190002506A1

  公开（公告）日：2019-01-03

  Provided herein is a platform technology for designing stabilized peptides that covalently bind their target protein and thereby inhibit the activity of the target protein. Also provided are exemplary stabilized peptides that can be used for covalent modification of their target proteins.
• [EN] STABILIZED PEPTIDES FOR COVALENT BINDING TO TARGET PROTEIN<br/>[FR] PEPTIDES STABILISÉS PERMETTANT UNE LIAISON COVALENTE AVEC UNE PROTÉINE CIBLE
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2017040323A2

  公开（公告）日：2017-03-09

  Provided herein is a platform technology for designing stabilized peptides that covalently bind their target protein and thereby inhibit the activity of the target protein. Also provided are exemplary stabilized peptides that can be used for covalent modification of their target proteins.