1-Methyl-4-(1-hydroxy-1-propyl)-piperidin | 50469-00-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-Methyl-4-(1-hydroxy-1-propyl)-piperidin
• 英文别名: 1-(1-methyl-piperidin-4-yl)-propan-1-ol；1-(1-Methylpiperidin-4-yl)propan-1-ol
• CAS: 50469-00-6
• 化学式: C₉H₁₉NO
• 分子量: 157.256
• InChiKey: SISYAXXMXROTMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH A CYCLIC AMINO GROUP AS CRF ANTAGONISTS
  申请人：NAKAZATO Atsuro

  公开号：US20110124862A1

  公开（公告）日：2011-05-26

  [Problem to be Solved] An object of the present invention is to provide an antagonist against CRF receptors and/or an agonist for δ receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. [Solution] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following formula [I] has a high affinity for CRF receptors and/or δ receptors, and is effective against diseases in which CRF is considered to be involved.

  【待解决的问题】本发明的目的是提供一种CRF受体的拮抗剂和/或δ受体的激动剂，作为治疗或预防CRF参与的疾病（如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈病、进食障碍、高血压、胃肠疾病、药物依赖、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、癫痫、皮炎、精神分裂症、疼痛等）的有效药物。 【解决方案】以下式[I]所表示的带有环状氨基基团的吡咯吡嘧啶或吡咯吡啶衍生物具有高亲和力，可作为CRF受体和/或δ受体的拮抗剂，对于CRF参与的疾病具有治疗效果。