tert-butyl N-[trans-3-methylpiperidin-4-yl]carbamate | 473839-07-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl N-[trans-3-methylpiperidin-4-yl]carbamate
• 英文别名: tert-butyl N-[(3R,4R)-3-methylpiperidin-4-yl]carbamate
• CAS: 473839-07-5
• 化学式: C₁₁H₂₂N₂O₂
• 分子量: 214.308
• InChiKey: LHSNRJGZDUFKQT-RKDXNWHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE
  申请人：Tsuboike Kazunari

  公开号：US20120149902A1

  公开（公告）日：2012-06-14

  Provided is a compound represented by the Formula (I) having a HER2 inhibitory action or a pharmacologically acceptable salt thereof, wherein T 1 is a phenyl group, an indazolyl group, or a benzofuryl group, n is an integer of 0 to 3, R 1 is a hydrogen atom, a halogen atom, a C 1-4 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, or a C 1-4 alkoxy group, m is an integer of 0 to 3, R 2 is a hydroxy group or a C 1-4 alkyl group optionally substituted with one or two C 1-4 alkoxy groups, and R 3 is a hydrogen atom, a C 1-4 alkyl group, or a C 2-6 alkynyl group.

  提供的是由式（I）表示的化合物，具有HER2抑制作用或其药理学上可接受的盐， 其中T 1 是苯基、吲唑基或苯并呋喃基，n为0至3的整数，R 1 是氢原子、卤原子、C 1-4 烷基、C 2-6 烯基、C 2-6 炔基或C 1-4 烷氧基，m为0至3的整数，R 2 是羟基或一个或两个C 1-4 烷氧基可选择地取代的C 1-4 烷基，R 3 是氢原子、C 1-4 烷基或C 2-6 炔基。
• Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation,compositions and use as medicaments
  申请人：WOCKHARDT LIMITED

  公开号：US20030216568A1

  公开（公告）日：2003-11-20

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗菌7-取代哌啶酮羧酸衍生物，以及它们的光学异构体、对映异构体或对映体，以及其药学上可接受的盐、水合物、前药、多晶形和假多晶形，以及它们的制备、组成和用途。
• Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-Quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
  申请人：WOCKHARDT LIMITED

  公开号：US20030096812A1

  公开（公告）日：2003-05-22

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗微生物7-取代哌啶酮羧酸衍生物，其光学异构体，对映异构体或对映体，以及其药学上可接受的盐，水合物，前药，多晶形和假多晶形，以及其制备，组成和使用。
• Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
  申请人：De Souza John Noel

  公开号：US20050065164A1

  公开（公告）日：2005-03-24

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向、手性、广谱抗微生物的7-取代哌啶酮羧酸衍生物，以及它们的光学异构体、对映异构体或对映体、药学上可接受的盐、水合物、前药、多晶型和假多晶型，以及它们的制备、组合物和用途。
• New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
  申请人：De Souza Noel John

  公开号：US20080214608A1

  公开（公告）日：2008-09-04

  This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

  本发明涉及新一代三重靶向手性广谱抗微生物7-取代哌啶酮羧酸衍生物，以及它们的光学异构体、对映异构体或对映体，以及药学上可接受的盐、水合物、前药、多晶形和伪多晶形，以及它们的制备、组成和使用。