4-(4-溴苯基)哌啶-4-醇盐酸盐 | 213480-97-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-(4-溴苯基)哌啶-4-醇盐酸盐
• 英文名称: 4-(4-bromophenyl)-piperidin-4-ol hydrochloride
• 英文别名: 4-(4-Bromophenyl)piperidin-4-ol hydrochloride；4-(4-bromophenyl)piperidin-4-ol;hydrochloride
• CAS: 213480-97-8
• 化学式: C₁₁H₁₄BrNO*ClH
• 分子量: 292.603
• InChiKey: DBZKQRKEZICYCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.44
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  32.3
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-溴苯基)哌啶-4-醇盐酸盐 在 盐酸 作用下， 以 水 为溶剂， 反应 5.0h， 以68%的产率得到4-(4-溴苯基)-1,2,3,6-四氢吡啶盐酸盐
  参考文献：
  名称：

  Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6-tetrahydropyridines as 5-HT2C agonists

  摘要：

  A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.122

文献信息

• Spray formulations of antihyperalgesic opiates and method of treating
  申请人：Adolor Corporation

  公开号：US05798093A1

  公开（公告）日：1998-08-25

  Spray formulations of anti-pruritic opiates having a peripheral selectivity of 251 to 1,280 in a solvent mixture of up to 15% w/w alcohol selected from the group consisting of ethyl, propyl and isopropyl alcohol and water greater than or equal to 85% w/w water.

  抗瘙痒鸦片类喷雾剂的制剂，具有外周选择性为251至1,280，在溶剂混合物中含有最多15%w/w的乙醇，所选乙醇包括乙醇、丙醇和异丙醇，水含量大于或等于85%w/w。
• EP1011647A4
  申请人：——

  公开号：EP1011647A4

  公开（公告）日：2001-05-16
• SPRAY FORMULATIONS OF ANTIHYPERALGESIC OPIATES AND METHOD OF TREATING TOPICAL HYPERALGESIC CONDITIONS AND PRURITUS THEREWITH
  申请人：Adolor Corporation

  公开号：EP1011647A1

  公开（公告）日：2000-06-28
• US5798093A
  申请人：——

  公开号：US5798093A

  公开（公告）日：1998-08-25
• US5811078A
  申请人：——

  公开号：US5811078A

  公开（公告）日：1998-09-22