Metformin/Repaglinide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Metformin/Repaglinide
• 英文别名: 3-(diaminomethylidene)-1,1-dimethylguanidine;2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid
• 化学式: C31H47N7O4
• 分子量: 581.7
• InChiKey: HPWIKAVXRHCHPE-BQAIUKQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.98
• 重原子数：
  42
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  170
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• COMPOSITE PRODUCT CONTAINING LIMONIN COMPOUND AND BIGUANIDE COMPOUND
  申请人：Zhejiang Yangshengtang Institute Of Natural Medication Co., Ltd.

  公开号：EP3666267A1

  公开（公告）日：2020-06-17

  The present invention relates to a combination product comprising a limonoid compound (or a pharmaceutically acceptable derivative, ester, stereoisomer, salt or prodrug thereof), and a biguanide compound (e.g., metformin, metformin hydrochloride, buformin, and phenformin). The present invention further relates to a use of the combination product for prevention and/or treatment of a disease associated with diabetes, for lipid-lowering and weight-loss, and the like.

  本发明涉及一种复方制剂，包括一种柠檬酸类化合物（或其药学上可接受的衍生物、酯、立体异构体、盐或原药）和一种双胍类化合物（如二甲双胍、盐酸二甲双胍、布福明和苯福明）。本发明进一步涉及组合产品在预防和/或治疗糖尿病相关疾病、降脂减肥等方面的用途。
• COMBINATION PRODUCT CONTAINING LIMONOID COMPOUND AND BIGUANIDE COMPOUND
  申请人：ZHEJIANG YANGSHENGTANG INSTITUTE OF NATURAL MEDICATION CO., LTD.

  公开号：US20220125757A1

  公开（公告）日：2022-04-28

  The present invention relates to a combination product comprising a limonoid compound (or a pharmaceutically acceptable derivative, ester, stereoisomer, salt or prodrug thereof), and a biguanide compound (e.g., metformin, metformin hydrochloride, buformin, and phenformin). The present invention further relates to a use of the combination product for prevention and/or treatment of a disease associated with diabetes, for lipid-lowering and weight-loss, and the like.