2-[4-(piperidin-1-yl)phenyl]-N-(pyrimidin-4-yl)propanamide | 1299294-89-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-[4-(piperidin-1-yl)phenyl]-N-(pyrimidin-4-yl)propanamide
• 英文别名: 2-(4-piperidin-1-ylphenyl)-N-pyrimidin-4-ylpropanamide
• CAS: 1299294-89-5
• 化学式: C₁₈H₂₂N₄O
• 分子量: 310.399
• InChiKey: CLGLNWNKNSBWGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  58.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] 2-ARYL-PROPIONAMIDE DERIVATIVES USEFUL AS BRADYKININ RECEPTOR ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DÉRIVÉS DE 1-ARYL-PROPIONAMIDE UTILES COMME ANTAGONISTES DES RÉCEPTEURS DE LA BRADYKININE ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：DOMPE SPA

  公开号：WO2011051375A1

  公开（公告）日：2011-05-05

  (R,S) 2-aryl-propionamide derivatives, or their single enantiomers (R) and (S) are disclosed useful in the treatment or prevention of symptoms and disorders such as pain and inflammation associated with the bradykinin B1 pathway.

  (R,S) 2-芳基丙酰胺衍生物，或其单对映体(R)和(S)，被披露用于治疗或预防与布雷金肽B1途径相关的症状和疾病，如疼痛和炎症。
• 2-aryl-propionamide derivatives useful as bradykinin receptor antagonists and pharmaceutical compositions containing them
  申请人：Dompe S.p.A.

  公开号：EP2316820A1

  公开（公告）日：2011-05-04

  (R,S) 2-aryl-propionamide derivatives, or their single enantiomers (R) and (S) are disclosed useful in the treatment or prevention of symptoms and disorders such as pain and inflammation associated with the bradykinin B1 pathway.

  (R,S) 2-芳基丙酰胺衍生物，或其单对映体(R)和(S)，被披露为在治疗或预防与布雷金肽B1通路相关的疼痛和炎症症状和疾病中有用。
• 2-ARYL-PROPIONAMIDE DERIVATIVES USEFUL AS BRADYKININ RECEPTOR ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Beccari Andrea

  公开号：US20120316169A1

  公开（公告）日：2012-12-13

  (R,S) 2-aryl-propionamide derivatives, or their single enantiomers (R) and (S) are disclosed useful in the treatment or prevention of symptoms and disorders such as pain and inflammation associated with the bradykinin B1 pathway.

  本文披露了(R,S) 2-芳基丙酰胺衍生物，或其单一对映体(R)和(S)，适用于治疗或预防与布雷金肽B1途径相关的疼痛和炎症等症状和疾病。