6-chloro-N2,N4-di-[2]pyridyl-[1,3,5]triazine-2,4-diyldiamine | 100398-65-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 6-chloro-N2,N4-di-[2]pyridyl-[1,3,5]triazine-2,4-diyldiamine
• 英文别名: 6-chloro-N²,N⁴-di-[2]pyridyl-[1,3,5]triazine-2,4-diyldiamine；6-Chlor-N²,N⁴-di-[2]pyridyl-[1,3,5]triazin-2,4-diyldiamin
• CAS: 100398-65-0
• 化学式: C₁₃H₁₀ClN₇
• 分子量: 299.722
• InChiKey: KIYYUDFMPATJOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.51
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  6-chloro-N2,N4-di-[2]pyridyl-[1,3,5]triazine-2,4-diyldiamine 在 palladium on activated charcoal 、 乙醇 作用下， 生成 N²,N⁴-di-[2]pyridyl-[1,3,5]triazine-2,4-diyldiamine
  参考文献：
  名称：

  Foye; Weinswig, Journal of the American Pharmaceutical Association (1912), 1959, vol. 48, p. 327

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基吡啶 、 三聚氯氰 在 碳酸氢钠 作用下， 以 丙酮 为溶剂， 生成 6-chloro-N2,N4-di-[2]pyridyl-[1,3,5]triazine-2,4-diyldiamine
  参考文献：
  名称：

  Synthesis and biological evaluation of some new 3,4-dihydropyrimidin-4-ones

  摘要：

  Condensation of 5-cyano-2-hydrazino-3-N-methyl-6-phenyl/p-chlorophenyl-3,4-dihydropyrimidin-4-one (3a and 3b) with 2 4-bisalkyl/arylamino-6-chloro-s-triazine (4) gave the corresponding 2,4-bisalkyl/arylamino-6-[5'-cyano-3'-N-methyl]-6'-phenyl/p-chlorophenyl-3',4'-dihydropyrimidin-4'-one-2'-yl-hydrazino-s-triazines (5a-n and 6a-n). The compounds 4 have been prepared by the condensation of cyanuric chloride and different alkyl/aryl amines. The reaction between 5-cyano-3-N-methyl-2-methylthio-6-phenyl/p-chlorophenyl-3,4-dihydropyrimidin-4-one (2a and 2b) with hydrazine hydrate furnished 3a and 3b, respectively. The condensation of 6-phenyl/p-chlorophenyl/5-cyano-2-mercapto-3,4-dihydropyrimidin-4-one (1a and 1b) with methyl iodide yielded 2a and 2b, respectively. All the products have been evaluated in vitro for their antimicrobial activity against several microbes and antitubercular activity against Mycobacterium tuberculosis H37 Rv. (C) 2001 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01118-1

文献信息

• Foye; Buckpitt, Journal of the American Pharmaceutical Association (1912), 1952, vol. 41, p. 385
  作者：Foye、Buckpitt

  DOI：——

  日期：——