[3-(11-fluoro-1,8-dithia-dibenzo[e,h]azulene-2-ylmethoxy)-propyl]-dimethyl-amine hydrochloride | 374800-21-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫平类
• 英文名称: [3-(11-fluoro-1,8-dithia-dibenzo[e,h]azulene-2-ylmethoxy)-propyl]-dimethyl-amine hydrochloride
• 英文别名: 3-[(17-fluoro-3,13-dithiatetracyclo[12.4.0.02,6.07,12]octadeca-1(14),2(6),4,7,9,11,15,17-octaen-4-yl)methoxy]-N,N-dimethylpropan-1-amine;hydrochloride
• CAS: 374800-21-2
• 化学式: C₂₂H₂₂FNOS₂*ClH
• 分子量: 436.014
• InChiKey: PZTWGYLYUSSQMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.58
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
  申请人：Pliva farmaceutska industrija, dionicko drustvo

  公开号：US20030153750A1

  公开（公告）日：2003-08-14

  The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-&agr;) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain.

  本发明涉及由公式I表示的二苯并蓝化合物，以及它们的制药制剂，用于抑制哺乳动物在所有过度分泌这些介质的疾病和情况中的肿瘤坏死因子α（TNF-α）和白细胞介素1（IL-1）。本发明的化合物还表现出镇痛作用，可用于缓解疼痛。
• THIENODIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS
  申请人：GlaxoSmithKline istrazivacki centar Zagreb d.o.o.

  公开号：EP1284977B1

  公开（公告）日：2009-06-24
• 4,5-DIHYDRO-[1,2,4]TRIAZOLO[4,3-F]PTERIDINES AS PROTEIN KINASE PLK1 INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP2010542A2

  公开（公告）日：2009-01-07
• US6897211B2
  申请人：——

  公开号：US6897211B2

  公开（公告）日：2005-05-24
• [EN] TETRAHYDROPTERIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES<br/>[FR] TÉTRAHYDROPTÉRIDINES SERVANT D'INHIBITEURS DE PROTEINES KINASES
  申请人：VERTEX PHARMA

  公开号：WO2007120752A2

  公开（公告）日：2007-10-25

  [EN] The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
  [FR] L'invention concerne des composés servant d'inhibiteurs de protéines kinases. L'invention concerne également des compositions pharmaceutiquement acceptables comprenant ces composés et des procédés d'utilisation de ces compositions visant à traiter des maladies, des troubles et des états pathologiques variés. L'invention concerne également des procédés destinés à préparer les composés de l'invention,