(2R,4R)-2-(4-azidomethyl-1-naphthylmethyl)-4-mesyloxy-N-(p-nitrobenzyloxycarbonyl)pyrrolidine | 170586-87-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (2R,4R)-2-(4-azidomethyl-1-naphthylmethyl)-4-mesyloxy-N-(p-nitrobenzyloxycarbonyl)pyrrolidine
• 英文别名: (4-nitrophenyl)methyl (2R,4R)-2-[[4-(azidomethyl)naphthalen-1-yl]methyl]-4-methylsulfonyloxypyrrolidine-1-carboxylate
• CAS: 170586-87-5
• 化学式: C₂₅H₂₅N₅O₇S
• 分子量: 539.569
• InChiKey: AKGQJJSVGFRECY-FGZHOGPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  142
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• CARBAPENEM DERIVATIVE
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0747381A1

  公开（公告）日：1996-12-11

  A compound of the formula: wherein R1 is a hydrogen atom or a lower alkyl group, R2 is a hydrogen atom or a negative charge, R3 is a hydrogen atom or a lower alkyl group, Ar is a phenyl group, a naphthyl group or a group of: (wherein each of A4 and A5 is a single bond, -NHSO2- or the like, and Het is a pyrrolinyl group, a 1,4-diazabicyclo[2.2.2]octanyl group or the like which may be substituted with a hydroxyl group, a carbamoyl lower alkyl group or the like) which may be substituted with a lower alkyl group, a lower alkylsulfamoyl group or the like which may be substituted with a hydroxyl group, a di-lower alkylsulfonyl group or the like; a hydroxyl group; a di-lower alkylsulfamoyl group or the like, each of A1, A2 and A3 is a single bond or a lower alkylene group which may be substituted with a lower alkyl group, a lower alkylsulfamoyl group or the like which may be substituted with a hydroxyl group, a di-lower alkylsulfamoyl group or the like; a pyridyl group or a pyridinio group or the like which may be substituted with a lower alkyl group, a carbamoyl lower alkyl group or the like, and W is a sulfur atom, a single bond or the like; or a pharmaceutically acceptable salt or ester thereof, a process for its production and an antibacterial agent containing it as an active ingredient.

  式的化合物： 其中 R1 是氢原子或低级烷基，R2 是氢原子或负电荷，R3 是氢原子或低级烷基，Ar 是苯基、萘基或以下基团： (其中 A4 和 A5 各为单键、-NHSO2- 或类似物，Het 为吡咯烷基、1,4-二氮杂双环[2.2.2]辛烷基或类似物，可被羟基、氨基甲酰基低级烷基或类似物取代），可被羟基、二低级烷基磺酰基或类似物取代；羟基；二低级烷基磺酰胺基或类似基团，A1、A2 和 A3 各为单键或可被低级烷基、低级烷基磺酰胺基或类似基团取代的低级亚烷基，可被羟基、二低级烷基磺酰胺基或类似基团取代；可被低级烷基、氨基甲酰基低级烷基或类似基团取代的吡啶基或吡啶硫基，且 W 为硫原子、单键或类似键；或其药学上可接受的盐或酯、其生产工艺以及含有其作为活性成分的抗菌剂。
• US5707987A
  申请人：——

  公开号：US5707987A

  公开（公告）日：1998-01-13