4-(4-苯氧基苄基)哌啶 | 955315-01-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-(4-苯氧基苄基)哌啶
• 英文名称: 4-(4-Phenoxy-benzyl)-piperidine
• 英文别名: 4-[(4-phenoxyphenyl)methyl]piperidine
• CAS: 955315-01-2
• 化学式: C₁₈H₂₁NO
• 分子量: 267.4
• InChiKey: DJKNMWGWPJMNMM-UHFFFAOYSA-N

物化性质

• 沸点：
  398.5±30.0 °C(Predicted)
• 密度：
  1.063±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• New 4 - substituted piperidines
  申请人：——

  公开号：US20020038031A1

  公开（公告）日：2002-03-28

  New 4-substituted piperidines of the following general formula (I) are disclosed in which R 1 and R 2 are substituted in unsubstituted aryl radicals, which compounds are obtained as racemic mixtures and as pure enantiomers. 1 The compounds, and their pharmaceutically acceptable salts, inhibit the serotonin and/or noradrenaline reuptake, and are useful as medicaments in disorders in which an increase of levels of those neurotransmitters is necessary.

  以下一般式（I）的新4-取代哌啶化合物被披露，其中R1和R2被取代为未取代芳基基团，这些化合物以外消旋混合物和纯对映体的形式获得。这些化合物及其药学上可接受的盐抑制5-羟色胺和/或去甲肾上腺素的再摄取，并且在需要增加这些神经递质水平的疾病中作为药物是有用的。
• 4-[(Aryl)(aryloxy)methyl]piperidine derivatives and their use as serotonin and/or noradrenaline reuptake inhibitors
  申请人：FAES, Fabrica Espanola de Productos Quimicos y Farmaceuticos, S.A.

  公开号：EP1002794A1

  公开（公告）日：2000-05-24

  New 4-substituted piperidines of general formula (I) are described    in which groups R1 and R2 are non-substituted aryl radicals or aryl radicals mono- or poly-substituted with halogen (fluorine, chlorine, bromine, iodine), alkyl, alkoxy, cyano, trifluoromethoxy, trifluoromethyl, benzoyl, phenyl, nitro, amino, aminoalkyl, aminoaryl and carbonylamino. These compounds, and their pharmaceutically acceptable salts, inhibit serotonin and/or noradrenaline reuptake, and are useful as antidepressants. Other potential therapeutic applications of these compounds are treatment of nervous bulimia, obsessive-compulsive disorders, alcohol addiction, anxiety, panic, pain, pre-menstrual syndrome and social phobia, as well as migraine prophylaxis.

  描述了通式(I)的新的 4-取代哌啶化合物 其中基团 R1 和 R2 是非取代的芳基或被卤素（氟、氯、溴、碘）、烷基、烷氧基、氰基、三氟甲氧基、三氟甲基、苯甲酰基、苯基、硝基、氨基、氨基烷基、氨基芳基和羰基氨基单取代或多取代的芳基。 这些化合物及其药学上可接受的盐类可抑制血清素和/或去甲肾上腺素的再摄取，可用作抗抑郁剂。这些化合物的其他潜在治疗应用包括治疗神经性贪食症、强迫症、酒精成瘾、焦虑、恐慌、疼痛、经前期综合征和社交恐惧症，以及偏头痛预防。