4-Hydrazino-2,2,6,6-tetramethyl-piperidin | 98511-53-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-Hydrazino-2,2,6,6-tetramethyl-piperidin
• 英文别名: 4-hydrazino-2,2,6,6-tetramethyl-piperidine；4-Hydrazinyl-2,2,6,6-tetramethylpiperidine；(2,2,6,6-tetramethylpiperidin-4-yl)hydrazine
• CAS: 98511-53-6
• 化学式: C₉H₂₁N₃
• mdl: MFCD19201955
• 分子量: 171.286
• InChiKey: VPGAMIDIVDERLY-UHFFFAOYSA-N

物化性质

• 沸点：
  256.4±29.0 °C(Predicted)
• 密度：
  0.95±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.1
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Multipurpose polymer bound stabilizers
  申请人：ATOCHEM NORTH AMERICA, INC.

  公开号：EP0303986A2

  公开（公告）日：1989-02-22

  These are provided polymer bound stabilizers with recurring units selected from the formulas or both wherein the units occur, e.g., in the polymer back­bone, x is 0 or 1, R¹ and R² are, e.g., hydrogen, and each -- is the residue of a primary amino or hydrazido substituted stabilizer group selected from (a) hindered phenols, (b) hindered amine light stabilizers, (c) 2-hydroxybenzophenones, (d) 2-(2-hydroxyphenyl)-2H-benzotriazoles, (e) secondary aromatic amines, (f) benzothiazoles or benzimidazoles, (g) aryl salicylates, (h) salicylic acid derivatives (i) oxamide derivatives and (j) dialkyl sulfides, with the proviso that at least two different groups from (a) through (j) are attahced to the polymer. The polymeric stabilizers are prepared by the reaction of primary amino or hydrazido substituted stabilizers with some or all of the anhydride groups of the polymer or copolymer. They are not lost from the polymer by volatilization, migration or extraction, even at high temperature and may be used as concentrates to stabilize other polymers.

  这些聚合物结合稳定剂具有选自下列公式的重复单元 或两者，其中单元出现在聚合物骨架等处，x 为 0 或 1，R¹ 和 R² 为氢等，且每 -- 是伯氨基或肼基取代的稳定剂基团的残基，选自 (a) 受阻酚，(b) 受阻胺光稳定剂，(c) 2-羟基二苯甲酮，(d) 2-(2-羟基苯基)-2H-苯并三唑，(e) 仲芳香胺、(f) 苯并噻唑或苯并咪唑； (g) 芳基水杨酸盐； (h) 水杨酸衍生物； (i) 草酰胺衍生物；以及 (j) 二烷基硫化物，但聚合物中至少含有两个不同的(a)至(j)基团。聚合物稳定剂是通过伯氨基或肼基取代的稳定剂与聚合物或共聚物的部分或全部酸酐基团反应制备的。即使在高温条件下，它们也不会因挥发、迁移或萃取而从聚合物中流失，可用作稳定其他聚合物的浓缩物。
• HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE
  申请人：PTC THERAPEUTICS, INC.

  公开号：US20210238186A1

  公开（公告）日：2021-08-05

  The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
• US4863999A
  申请人：——

  公开号：US4863999A

  公开（公告）日：1989-09-05
• US4981915A
  申请人：——

  公开号：US4981915A

  公开（公告）日：1991-01-01
• US5096974A
  申请人：——

  公开号：US5096974A

  公开（公告）日：1992-03-17