1-(Pyrazin-2-yl)piperidine-3-carboxylic acid | 891392-96-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(Pyrazin-2-yl)piperidine-3-carboxylic acid
• 英文别名: 1-pyrazin-2-ylpiperidine-3-carboxylic acid
• CAS: 891392-96-4
• 化学式: C₁₀H₁₃N₃O₂
• mdl: MFCD09733196
• 分子量: 207.23
• InChiKey: DQZQBNKOVJNCRU-UHFFFAOYSA-N

物化性质

• 沸点：
  419.0±45.0 °C(Predicted)
• 密度：
  1.291±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] HEAT SHOCK PROTEIN 70 (HSP-70) RECEPTOR LIGANDS<br/>[FR] LIGANDS DE RÉCEPTEURS DE LA PROTÉINE DE CHOC THERMIQUE 70 (HSP-70)
  申请人：UNIV DUKE

  公开号：WO2015148714A1

  公开（公告）日：2015-10-01

  Inducible HSP70 is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis and poor outcomes to radiation and chemotherapy in patients. Identification of small molecule inhibitors of HSP70 pose a new therapy to cancer treatment. HS72, a benzimidazole piperidinyl carboxamide has been identified as an allosteric inhibitor for HSP70 and has demonstrated good tumor growth inhibition in vivo.

  可诱导的HSP70在广泛的人类肿瘤中过度表达，其表达与患者的转移和对放疗、化疗的不良结果相关。寻找HSP70的小分子抑制剂为癌症治疗提供了新的途径。HS72，一种苯并咪唑哌啶基羧酰胺，已被确定为HSP70的一个变构抑制剂，并在体内显示出良好的肿瘤生长抑制作用。
• Heat shock protein 70 (hsp-70) receptor ligands
  申请人：Duke University

  公开号：US10000469B2

  公开（公告）日：2018-06-19

  Inducible HSP70 is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis and poor outcomes to radiation and chemotherapy in patients. Identification of small molecule inhibitors of HSP70 pose a new therapy to cancer treatment. HS72, a benzimidazole piperidinyl carboxamide has been identified as an allosteric inhibitor for HSP70 and has demonstrated good tumor growth inhibition in vivo.

  诱导型 HSP70 在多种人类肿瘤中过度表达，其表达与肿瘤转移以及患者对放疗和化疗的不良反应有关。HSP70 小分子抑制剂的发现为癌症治疗提供了一种新疗法。HS72是一种苯并咪唑哌啶羧酰胺，已被确定为HSP70的异构抑制剂，并在体内显示出良好的肿瘤生长抑制作用。
• HEAT SHOCK PROTEIN 70 (HSP-70) RECEPTOR LIGANDS
  申请人：Duke University

  公开号：US20170174660A1

  公开（公告）日：2017-06-22

  Inducible HSP70 is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis and poor outcomes to radiation and chemotherapy in patients. Identification of small molecule inhibitors of HSP70 pose a new therapy to cancer treatment. HS72, a benzimidazole piperidinyl carboxamide has been identified as an allosteric inhibitor for HSP70 and has demonstrated good tumor growth inhibition in vivo.