Diphenyl-carbamic acid 7-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-(dimethylamino-methyleneamino)-7H-purin-2-yl ester | 676448-32-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Diphenyl-carbamic acid 7-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-(dimethylamino-methyleneamino)-7H-purin-2-yl ester
• CAS: 676448-32-1
• 化学式: C₄₇H₄₅N₇O₇
• 分子量: 819.917
• InChiKey: HPSYVHKTUFPBCX-NJZAESGASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.06
• 重原子数：
  61.0
• 可旋转键数：
  14.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  145.89
• 氢给体数：
  1.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  2-氰乙基N,N-二异丙基氯亚磷酰胺 、 Diphenyl-carbamic acid 7-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-(dimethylamino-methyleneamino)-7H-purin-2-yl ester 以60%的产率得到
  参考文献：
  名称：

  Oligonucleotides Incorporating N⁷-(2′-Deoxy-β-d-erythro-pentofuranosyl)isoguanine

  摘要：

  The H-phosphonate and the phosphoramidite of N-7-2'-deoxyisoguanosine (2) were prepared and incorporated into oligonucleotide duplexes. Their base pairing properties were investigated and compared with those of the parent purine nucleosides.

  DOI：

  10.1081/ncn-120022844
• 作为产物：
  描述：

  二苯氨基甲酰氯 生成 Diphenyl-carbamic acid 7-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-(dimethylamino-methyleneamino)-7H-purin-2-yl ester
  参考文献：
  名称：

  Oligonucleotides Incorporating N⁷-(2′-Deoxy-β-d-erythro-pentofuranosyl)isoguanine

  摘要：

  The H-phosphonate and the phosphoramidite of N-7-2'-deoxyisoguanosine (2) were prepared and incorporated into oligonucleotide duplexes. Their base pairing properties were investigated and compared with those of the parent purine nucleosides.

  DOI：

  10.1081/ncn-120022844