| 184159-47-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 184159-47-5
• 化学式: C₄₉H₄₅N₄O₉P
• 分子量: 864.891
• InChiKey: GYEZNEFGILLCEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.66
• 重原子数：
  63.0
• 可旋转键数：
  19.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  147.52
• 氢给体数：
  1.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 生成
  参考文献：
  名称：

  Synthesis And Binding Study Of Phosphonate Analogues Of Pnas And Their Hybrids With Pnas

  摘要：

  The preparation of monomers for time synthesis of phosphonate analogues of peptide nucleic acids containing the four natural nucleobases: thymine, cytosine, adenine and guanine, has been ccomplished. The monomers obtained were used for the automated online solid phase synthesis of pure phosphono-PNA oligomers as well as chimeras consisting of phosphono-PNA and]PNA resudies. The hybridization properties of these oligonucleotide mimics to complementary DNA and RNA fragments were studied.

  DOI：

  10.1080/07328319808004700
• 作为产物：
  描述：

  亚磷酸二苯酯 在 N,N'-二环己基碳二亚胺 作用下， 生成
  参考文献：
  名称：

  Synthesis And Binding Study Of Phosphonate Analogues Of Pnas And Their Hybrids With Pnas

  摘要：

  The preparation of monomers for time synthesis of phosphonate analogues of peptide nucleic acids containing the four natural nucleobases: thymine, cytosine, adenine and guanine, has been ccomplished. The monomers obtained were used for the automated online solid phase synthesis of pure phosphono-PNA oligomers as well as chimeras consisting of phosphono-PNA and]PNA resudies. The hybridization properties of these oligonucleotide mimics to complementary DNA and RNA fragments were studied.

  DOI：

  10.1080/07328319808004700

文献信息

• An approach towards the synthesis of oligomers containing a N-2-hydroxyethyl-aminomethylphosphonate backbone: A novel PNA analogue
  作者：Alexander C. van der Laan、Roger Strömberg、Jacques H. van Boom、Esther Kuyl-Yeheskiely、Vladimir A. Efimov、Oksana G. Chakhmakhcheva

  DOI：10.1016/0040-4039(96)01750-9

  日期：1996.10

  A convenient route to the preparation of 4-methoxy-1-oxido-pyridine-2-methyl N-2-(4,4′-dimethoxytrityloxy)ethyl-N-thymin-1-yl-aminomethylphosphonate (1a, T∗) and the corresponding N4-benzoylcytosin-1-yl derivative 1b (C∗) is reported. These PPNA monomers proved to be suitable building blocks in a solid-support synthesis of the tetradecameric fragment (C∗T∗T∗T∗C∗T∗T∗T∗T∗C∗T∗C∗T∗)dT.

  制备4-甲氧基-1-氧化吡啶-2-甲基N -2-（4,4'-二甲氧基三苯甲氧基）乙基-N-胸腺嘧啶-1-基-氨基甲基膦酸酯（1a，T ∗）和报道了相应的N 4-苯甲酰基胞嘧啶-1-基衍生物1b（C ∗）。这些PPNA单体被证明是固相合成十四聚体片段的基础材料（C * T * T * T * T * C * T * T * T * T * C * T *C ∗ T ∗）dT。