N-methyl-N-(piperidin-4-yl)-5-(1-(4-(trifluoromethyl)phenyl)piperidin-4-yloxy)benzofuran-2-carboxamide | 1152424-26-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-methyl-N-(piperidin-4-yl)-5-(1-(4-(trifluoromethyl)phenyl)piperidin-4-yloxy)benzofuran-2-carboxamide
• 英文别名: N-methyl-N-piperidin-4-yl-5-[1-[4-(trifluoromethyl)phenyl]piperidin-4-yl]oxy-1-benzofuran-2-carboxamide
• CAS: 1152424-26-4
• 化学式: C₂₇H₃₀F₃N₃O₃
• 分子量: 501.549
• InChiKey: PRYPKLUZOLVVNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  58
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• AMPK-Activating Heterocycloalkyloxy(Hetero)Aryl Carboxamide, Sulfonamide And Amine Compounds And Methods For Using The Same
  申请人：Hong Hui

  公开号：US20120115838A1

  公开（公告）日：2012-05-10

  Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R 1 , R 2 , R 4 , E, T, n and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

  本发明涉及羧酰胺、磺酰胺和胺类化合物，以及药物组合物和使用方法。其中一种实施方式是具有以下结构的化合物，其中R1、R2、R4、E、T、n和x如本文所述。在某些实施方式中，本文所披露的化合物可以激活AMPK通路，并可用于治疗代谢相关的疾病和症状。
• Carboxamide, Sulfonamide and Amine Compounds and Methods for Using Them
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20140378429A1

  公开（公告）日：2014-12-25

  The disclosure relates particularly to certain carboxamide, sulfonamide and amine compounds and pharmaceutical compositions thereof, and to methods of treating and ameliorating disorders and conditions related to the adiponectin pathway, sphingolipid metabolism, oxidative stress, mitochondrial dysfunction, free radical damage and metabolic inefficiency, among others. In certain embodiments, the compounds have the structures (I-1), (2-I) and (3-I) (The chemical formulas should be inserted here) in which the variables are as described herein.

  本公开涉及特定的羧酰胺、磺酰胺和胺化合物及其制药组合物，以及治疗和改善与脂联素途径、鞘脂代谢、氧化应激、线粒体功能障碍、自由基损伤和代谢效率等相关的疾病和病症的方法。在某些实施例中，化合物具有结构（I-1）、（2-I）和（3-I）（化学式应在此处插入），其中变量如本文所述。
• Carboxamide, Sulfonamide and Amine Compounds and Methods for Using The Same
  申请人：Hong Hui

  公开号：US20090170829A1

  公开（公告）日：2009-07-02

  Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R 1 , R 2 , R 4 , E, T, n and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

  本发明涉及羧酰胺、磺酰胺和胺化合物，以及制备药物组合物和使用方法。其中一种实施方式是具有下列结构的化合物： 其中R1、R2、R4、E、T、n和x的定义如本文所述。在某些实施方式中，本文所披露的化合物可以激活AMPK途径，并可用于治疗与代谢有关的疾病和症状。
• Perfume compositions and perfumed articles containing spiro-undecanones and -undecenones as perfume base
  申请人：NAARDEN INTERNATIONAL N.V.

  公开号：EP0074693A1

  公开（公告）日：1983-03-23

  Perfume compositions, perfumed materials and perfumed articles containing derivatives of spiro [5.5] undecane-3-one and/or undecene-3-one having the following formula wherein R, and R2 are hydrogen or methyl and the dotted line is a single or double bond with the proviso that when this dotted line is a double bond R1 and R2 are both hydrogen. The use of one or more derivatives of spiro 15.5] undecane-3-one and or -undecene-3-one having formula 1 as a perfume component in perfume compositions and in imparting fragrance to materials and articles for example soaps, cleaning preparations and cosmetic preparations.

  含有具有下式的螺[5.5]十一烷-3-酮和/或十一烯-3-酮衍生物的香水组合物、加香材料和加香物品 其中R和R2为氢或甲基，虚线为单键或双键，但当该虚线为双键时，R1和R2均为氢。 具有式1的一种或多种螺[15.5]十一烷-3-酮和/或十一烯-3-酮衍生物作为香水成分在香水组合物中的用途，以及为肥皂、清洁制剂和化妆品制剂等材料和物品赋予香味的用途。
• Perfume compositions and perfumed articles containing one or more tetramethyl-tri-cycloundecyl-alkyl ketones as perfume component
  申请人：NAARDEN INTERNATIONAL N.V.

  公开号：EP0074694A2

  公开（公告）日：1983-03-23

  Perfume compositions, perfumed materials and perfumed articles containing one or more isomers of substituted 1.4.4.8-tetramethyl-tricyclo [6.3.0.025]-undecanes as perfume base. Use of one or more isomers of 9-alkanoyl-1.4.4.8-tetramethyl-tricyclo [6.3.0.025] undecanes having formula wherein R is methyl, ethyl or n-propyl as a perfume component in perfume compositions and in imparting fragrance to materials and articles for example soaps, cleaning preparations and cosmetic preparations.

  含有一种或多种取代的1.4.4.8-四甲基-三环[6.3.0.025]十一烷异构体作为香水基料的香水组合物、香水材料和香水制品。 使用 9-烷酰基-1.4.4.8-四甲基-三环[6.3.0.025]十一烷的一种或多种异构体，其式为 其中 R 为甲基、乙基或正丙基的一种或多种异构体，可用作香水组合物中的香料成分，以及为肥皂、清洁制剂和化妆品等材料和物品增添香味。