4-[1,1-Bis[4-hydroxy-3,5-bis(piperidin-1-ylmethyl)phenyl]ethyl]-2,6-bis(piperidin-1-ylmethyl)phenol | 1086840-23-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[1,1-Bis[4-hydroxy-3,5-bis(piperidin-1-ylmethyl)phenyl]ethyl]-2,6-bis(piperidin-1-ylmethyl)phenol
• CAS: 1086840-23-4
• 化学式: C₅₆H₈₄N₆O₃
• 分子量: 889.321
• InChiKey: LRERPDFQIVAIRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  65
• 可旋转键数：
  15
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  80.1
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Telomerase activating compounds and their use
  申请人：Ben Gurion University Of The Negev Research And Development Authority

  公开号：EP2826472A2

  公开（公告）日：2015-01-21

  The present invention is directed to use of a series of compounds represented by the structure of formula I and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto:

  本发明涉及以式 I 结构为代表的一系列化合物和包含这些化合物的组合物，用于激活端粒酶和治疗与之相关的疾病、失调和/或病症：
• Telomerase activating compounds and methods of use thereof
  申请人：Ben Gurion University Of The Negev Research And Development Authority

  公开号：EP2152256B1

  公开（公告）日：2014-10-15
• Tri-aryl compounds and compositions comprising the same
  申请人：Ben Gurion University of the Negev Research and Development Authority

  公开号：EP2152663B1

  公开（公告）日：2014-03-19
• TRI-ARYL COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME
  申请人：Priel Esther

  公开号：US20100256382A1

  公开（公告）日：2010-10-07

  The present invention relates to a novel class of tri-aryl compounds, compositions comprising the same and processes for the preparation thereof.
• TELOMERASE ACTIVATING COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Gazit Aviv

  公开号：US20100267667A1

  公开（公告）日：2010-10-21

  The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto.