| 215812-30-9

• CAS: 215812-30-9
• 化学式: C₁₅H₁₄FeN₂O₅S
• 分子量: 390.2
• InChiKey: KGYUWPLZFIDOKF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  [CpFe(CO)2(η1-N-(4-aminobenzenesulfonamido))] 、 乙酸酐 以 乙酸酐 为溶剂， 以86%的产率得到
  参考文献：
  名称：

  (η5-Cyclopentadienyl)Fe(CO)2-complexes of sulfonamide anions. Acylation of the amino group in the sulfanilamide complex and its relevance to the protein labelling

  摘要：

  Illumination with visible light of [CpFe(CO)(2)I] (Cp = eta(5)-C5H5) with NH2SO2C6H4-p-R (R = Me, NO2, NH2) in benzene in the presence of diisopropylamine gives [CpFe(CO)(2)NHSO2C6H4-p-R] in 62-91% yield. The primary amino group in [CpFe(CO)(2)NHSO2C6H4-p-NH2] was acylated by treatment of this complex with neat carboxylic acid anhydrides (acetic, propionic and isobutyric) or with carboxylic acid (acetic, iodoacetic, beta-maleimidopropionic) and 1-[3-(dimethylamino)propyl]-3-ethyl-carbodiimide (EDC) in aqueous solutions at pH 5-6 at room temperature. The latter reaction shows that [CpFe(CO)(2)NHSO2C6H4-p-NH2] can be used as an IR-detectable metallo-carbonyl reagent labelling the COOH groups in proteins and as a parent compound for a new family of reagents labelling the thiol function. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-328x(98)00756-6